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Hdx Gene Detail
Summary
  • Symbol
    Hdx
  • Name
    highly divergent homeobox
  • Synonyms
    D030011N01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685226
    NCBI Gene: 245596
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:110484901-110606908 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 48.29 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1864 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685226
 protein coding gene ChrX:110479628-110606908 (-)
129S1/SvImJ ENSMUSG00200024044
 protein coding gene ChrX:92295659-92422814 (-)
A/J ENSMUSG00195026029
 protein coding gene ChrX:96016689-96145007 (-)
AKR/J ENSMUSG00220034289
 protein coding gene ChrX:90250037-90378355 (-)
BALB/cJ ENSMUSG00180025645
 protein coding gene ChrX:92684960-92813275 (-)
C3H/HeJ ENSMUSG00175027238
 protein coding gene ChrX:96290262-96418574 (-)
C57BL/6NJ ENSMUSG00215012819
 protein coding gene ChrX:92918065-93045193 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033351
 protein coding gene ChrX:104974629-105099954 (-)
CAST/EiJ ENSTCUG00005020534
 protein coding gene ChrX:93610190-93737340 (-)
CBA/J ENSMUSG00210022228
 protein coding gene ChrX:93157269-93285552 (-)
DBA/2J ENSMUSG00185029053
 protein coding gene ChrX:105624779-105751928 (-)
FVB/NJ ENSMUSG00205017935
 protein coding gene ChrX:92235455-92363763 (-)
JF1/MsJ ENSUMUG00000013728
 protein coding gene ChrX:126246763-126373749 (-)
LP/J ENSMUSG00230005139
 protein coding gene ChrX:112262140-112389289 (-)
NOD/ShiLtJ ENSMUSG00190013091
 protein coding gene ChrX:92367869-92495012 (-)
NZO/HlLtJ ENSMUSG00225039740
 protein coding gene ChrX:117409690-117544154 (-)
PWK/PhJ ENSLUMG00010025950
 protein coding gene ChrX:91519808-91646743 (-)
SPRET/EiJ ENSMSPG00010021384
 protein coding gene ChrX:95852653-95979481 (-)
WSB/EiJ ENSIUOG00005014951
 protein coding gene ChrX:92725481-92852645 (-)



Homology
more
  • Human Ortholog
    HDX, highly divergent homeobox
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HDX, highly divergent homeobox
  • Synonyms
    CXorf43, D030011N01Rik
  • Links
    NCBI Gene ID: 139324
    UniProt: Q7Z353

  • Chr Location
    Xq21.1; chrX:84317874-84502496 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 images
    9 phenotype references
Male chimeras hemizygous for a gene trapped allele appear normal at E9.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    635
  • Tissues
    23
  • cDNA Data
    11
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 245596 NCBI Gene Model | MGI Sequence Detail 122008 C57BL/6J ±  kb
transcript NM_001080549 RefSeq | MGI Sequence Detail 4261 C57BL/6  
polypeptide Q14B70 UniProt | EBI | MGI Sequence Detail 692 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11
    Antibodies 1

    Microarray probesets 2
References
more
  • Summaries
    All 33
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:257654 Memic F, et al., Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory