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Xirp2 Gene Detail
Summary
  • Symbol
    Xirp2
  • Name
    xin actin-binding repeat containing 2
  • Synonyms
    2310003D02Rik, 2310008C07Rik, A530024P18Rik, Cmya3, mXin beta, myomaxin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685198
    NCBI Gene: 241431
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:67276343-67356964 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 39.31 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2399 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685198
 protein coding gene Chr2:67004178-67356964 (+)
129S1/SvImJ ENSMUSG00200035480
 protein coding gene Chr2:64379955-64429197 (+)
A/J ENSMUSG00195021638
 protein coding gene Chr2:64503693-64553598 (+)
AKR/J ENSMUSG00220034629
 protein coding gene Chr2:64466889-64516183 (+)
BALB/cJ ENSMUSG00180037623
 protein coding gene Chr2:64462594-64512496 (+)
C3H/HeJ ENSMUSG00175034809
 protein coding gene Chr2:64554507-64603788 (+)
C57BL/6NJ ENSMUSG00215017039
 protein coding gene Chr2:64402006-64451892 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023610
 protein coding gene Chr2:62001429-62080557 (+)
CAST/EiJ ENSTCUG00005008462
 protein coding gene Chr2:63848797-63897768 (+)
CBA/J ENSMUSG00210032666
 protein coding gene Chr2:64597478-64646764 (+)
DBA/2J ENSMUSG00185038963
 protein coding gene Chr2:64455521-64504773 (+)
FVB/NJ ENSMUSG00205034042
 protein coding gene Chr2:63927431-63977335 (+)
JF1/MsJ ENSUMUG00000005832
 protein coding gene Chr2:64107344-64156719 (+)
LP/J ENSMUSG00230022172
 protein coding gene Chr2:66263525-66313421 (+)
NOD/ShiLtJ ENSMUSG00190033492
 protein coding gene Chr2:64525366-64574625 (+)
NZO/HlLtJ ENSMUSG00225014731
 protein coding gene Chr2:74004124-74053383 (+)
PWK/PhJ ENSLUMG00010032494
 protein coding gene Chr2:64267069-64316440 (+)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005019197
 protein coding gene Chr2:64576387-64625661 (+)



Homology
more
  • Human Ortholog
    XIRP2, xin actin binding repeat containing 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    XIRP2, xin actin binding repeat containing 2
  • Synonyms
    CMYA3
  • Links
    NCBI Gene ID: 129446
    UniProt: A4UGR9

  • Chr Location
    2q24.3; chr2:166888480-167259753 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human XIRP2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit severe growth retardation, abnormal myocardial fiber morphology, failure of intercalated disc maturation, cardiac conduction and ventricular septal defects, altered ionic currents in cardiomyocytes, and postnatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    646
  • Tissues
    15
  • cDNA Data
    16
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 241431 NCBI Gene Model | MGI Sequence Detail 80622 C57BL/6J ±  kb
    transcript NM_001083919 RefSeq | MGI Sequence Detail 11969 Not Specified  
    polypeptide Q4U4S6 UniProt | EBI | MGI Sequence Detail 3784 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 17
      Primer pair 4
      Antibodies 3

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1916705, MGI:1916775, MGI:2138966
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 5
      Gene Ontology 12
      Phenotypes 15
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:338149 Wagner EL, et al., Repair of noise-induced damage to stereocilia F-actin cores is facilitated by XIRP2 and its novel mechanosensor domain. Elife. 2023 Jun 9;12
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory