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Ccdc154 Gene Detail
Summary
  • Symbol
    Ccdc154
  • Name
    coiled-coil domain containing 154
  • Synonyms
    LOC207209, ntl
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685163
    NCBI Gene: 207209
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:25381435-25390887 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.53 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    111 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685163
 protein coding gene Chr17:25381142-25390887 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023341
 protein coding gene Chr17:24204784-24215488 (+)
A/J MGP_AJ_G0023300
 protein coding gene Chr17:23530512-23539908 (+)
AKR/J MGP_AKRJ_G0023266
 protein coding gene Chr17:23621371-23630796 (+)
BALB/cJ MGP_BALBcJ_G0023305
 protein coding gene Chr17:23727083-23736428 (+)
C3H/HeJ MGP_C3HHeJ_G0023065
 protein coding gene Chr17:23997899-24007282 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023748
 protein coding gene Chr17:25269151-25278603 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021223
 protein coding gene Chr17:20991092-21000549 (+)
CAST/EiJ MGP_CASTEiJ_G0022567
 protein coding gene Chr17:23844734-23854138 (+)
CBA/J MGP_CBAJ_G0023040
 protein coding gene Chr17:26126442-26137998 (+)
DBA/2J MGP_DBA2J_G0023170
 protein coding gene Chr17:23118796-23128192 (+)
FVB/NJ MGP_FVBNJ_G0023140
 protein coding gene Chr17:22840365-22850595 (+)
LP/J MGP_LPJ_G0023247
 protein coding gene Chr17:24498293-24507739 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023159
 protein coding gene Chr17:25790201-25799594 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023787
 protein coding gene Chr17:23903960-23913356 (+)
PWK/PhJ MGP_PWKPhJ_G0022316
 protein coding gene Chr17:21880399-21889853 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022134
 protein coding gene Chr17:21977223-21986712 (+)
WSB/EiJ MGP_WSBEiJ_G0022630
 protein coding gene Chr17:23975210-23984604 (+)



Homology
more
  • Human Ortholog
    CCDC154, coiled-coil domain containing 154
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCDC154, coiled-coil domain containing 154
  • Synonyms
    C16orf29
  • Links
    NCBI Gene ID: 645811
    neXtProt AC: NX_A6NI56
    UniProt: A6NI56

  • Chr Location
    16p13.3; chr16:1434383-1444556 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ccdc154 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit failure of tooth eruption, osteopetrosis, enlarged liver, decreased body size and premature death unless fed a liquid diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059562 Ensembl Gene Model | MGI Sequence Detail 9453 C57BL/6J ±  kb
    transcript ENSMUST00000182621 Ensembl | MGI Sequence Detail 2402 Not Applicable  
    polypeptide ENSMUSP00000138090 Ensembl | MGI Sequence Detail 664 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 3
      cDNA 3

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:5702427
    References
    more
    • Summaries
      All 24
      Diseases 1
      Gene Ontology 3
      Phenotypes 7
    • Earliest
      J:86784 Bergstrom DE, et al., Overlapping deletions spanning the proximal two-thirds of the mouse t complex. Mamm Genome. 2003 Dec;14(12):817-29
    • Latest
      J:314987 Xu K, et al., CCDC154 Mutant Caused Abnormal Remodeling of the Otic Capsule and Hearing Loss in Mice. Front Cell Dev Biol. 2021;9:637011
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory