Setdb2 MGI Mouse Gene Detail - MGI:2685139

Symbol

Setdb2
Name

SET domain, bifurcated 2
Synonyms

KMT1F, LOC239122

Feature Type

protein coding gene
IDs

MGI:2685139
NCBI Gene: 239122
Alliance

genome feature page

Sequence Map

Chr14:59639458-59678329 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 31.48 cM
Mapping Data

1 experiment

SNPs within 2kb

888 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2685139	protein coding gene	Chr14:59639458-59678333 (-)
129S1/SvImJ	ENSMUSG00200040718	protein coding gene	Chr14:48225353-48264238 (-)
A/J	ENSMUSG00195032629	protein coding gene	Chr14:48442758-48481635 (-)
AKR/J	ENSMUSG00220024790	protein coding gene	Chr14:47780746-47819608 (-)
BALB/cJ	ENSMUSG00180049360	protein coding gene	Chr14:48064750-48103633 (-)
C3H/HeJ	ENSMUSG00175045888	protein coding gene	Chr14:49783484-49822328 (-)
C57BL/6NJ	ENSMUSG00215048140	protein coding gene	Chr14:47963401-48002280 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019367	protein coding gene	Chr14:50633290-50672359 (-)
CAST/EiJ	ENSTCUG00005046363	protein coding gene	Chr14:49737078-49780356 (-)
CBA/J	ENSMUSG00210045027	protein coding gene	Chr14:48432989-48471867 (-)
DBA/2J	ENSMUSG00185030120	protein coding gene	Chr14:53581696-53620548 (-)
FVB/NJ	ENSMUSG00205020232	protein coding gene	Chr14:47867041-47905926 (-)
JF1/MsJ	ENSUMUG00000045777	protein coding gene	Chr14:64807462-64847717 (-)
LP/J	ENSMUSG00230032474	protein coding gene	Chr14:65594318-65633214 (-)
NOD/ShiLtJ	ENSMUSG00190027431	protein coding gene	Chr14:48197282-48236157 (-)
NZO/HlLtJ	ENSMUSG00225044611	protein coding gene	Chr14:55938867-55977748 (-)
PWK/PhJ	ENSLUMG00010042111	protein coding gene	Chr14:47650049-47688929 (-)
SPRET/EiJ	ENSMSPG00010031894	protein coding gene	Chr14:51111331-51153629 (-)
WSB/EiJ	ENSIUOG00005036794	protein coding gene	Chr14:47629254-47668127 (-)

Human Ortholog

SETDB2, SET domain bifurcated histone lysine methyltransferase 2

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SETDB2, SET domain bifurcated histone lysine methyltransferase 2
Synonyms

C13orf4, CLLD8, CLLL8, KMT1F
Links

HGNC:20263

NCBI Gene ID: 83852

UniProt: Q96T68
Chr Location

13q14.2; chr13:49443794-49495003 (+) GRCh38

MGI Vertebrate Homology

Setdb2 stringent orthology
1 human;1 mouse;3 rat;1 zebrafish
HCOP

vertebrate homology predictions: SETDB2
Gene Tree

Setdb2

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

4
Genomic Mutations

1 involving Setdb2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

54 strains or lines available

Mice homozygous for a hypomorphic allele exhibit altered response to infection and improved patology following superinfection of influenza virus-infected mice with S. pneumonia.

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All GO Annotations

33
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

736
Tissues

110
cDNA Data

28
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase setdb2

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All Sequences

59
RefSeq

6
UniProt

10
CCDS

CCDS36939.1, CCDS84142.1

Ensembl

ENSMUSG00000071350 (Evidence)
NCBI Gene

239122

			Length	Strain/Species	Flank
genomic	239122	NCBI Gene Model \| MGI Sequence Detail	38872	C57BL/6J	± kb
transcript	NM_001320720	RefSeq \| MGI Sequence Detail	3000	C57BL/6
polypeptide	Q8C267	UniProt \| EBI \| MGI Sequence Detail	713	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000014725 histone-lysine N-methyltransferase SETDB2

(term hierarchy)
EC

2.1.1.366
InterPro Domains

IPR016177 DNA-binding domain superfamily

IPR051516 Histone-lysine N-methyltransferase SETDB

IPR047232 Histone-lysine N-methyltransferase SETDB1/2-like, methyl-CpG binding domains

IPR001739 Methyl-CpG DNA binding

IPR007728 Pre-SET domain

IPR001214 SET domain

IPR046341 SET domain superfamily
GlyGen

Q8C267 1 site

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All nucleic 30

cDNA 28

Primer pair 2

Antibodies 1

Microarray probesets 1

Summaries

All 45

Developmental Gene Expression 5

Gene Ontology 8

Phenotypes 18
Earliest

J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
Latest

J:377577 Bauer TM, et al., TNF-alpha represses fibroblast to myofibroblast transition through the histone methyltransferase Setdb2. JCI Insight. 2025 Nov 24;10(22)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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