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Myrf Gene Detail
Summary
  • Symbol
    Myrf
  • Name
    myelin regulatory factor
  • Synonyms
    Gm98, LOC225908, LOC386531
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684944
    NCBI Gene: 225908
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:10185636-10218112 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 6.54 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    140 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684944
 protein coding gene Chr19:10185635-10218134 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024841
 protein coding gene Chr19:7531680-7565462 (-)
A/J MGP_AJ_G0024809
 protein coding gene Chr19:7015025-7047493 (-)
AKR/J MGP_AKRJ_G0024784
 protein coding gene Chr19:7295374-7327839 (-)
BALB/cJ MGP_BALBcJ_G0024809
 protein coding gene Chr19:7061789-7094274 (-)
C3H/HeJ MGP_C3HHeJ_G0024575
 protein coding gene Chr19:7183005-7215489 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025257
 protein coding gene Chr19:7878838-7918972 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022684
 protein coding gene Chr19:7432968-7465247 (-)
CAST/EiJ MGP_CASTEiJ_G0024048
 protein coding gene Chr19:6842942-6875194 (-)
CBA/J MGP_CBAJ_G0024549
 protein coding gene Chr19:7926275-7960350 (-)
DBA/2J MGP_DBA2J_G0024676
 protein coding gene Chr19:7028745-7061205 (-)
FVB/NJ MGP_FVBNJ_G0024643
 protein coding gene Chr19:7066398-7099622 (-)
LP/J MGP_LPJ_G0024763
 protein coding gene Chr19:7508186-7540662 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024670
 protein coding gene Chr19:7834151-7866446 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025305
 protein coding gene Chr19:7317981-7351628 (-)
PWK/PhJ MGP_PWKPhJ_G0023793
 protein coding gene Chr19:6468916-6501524 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023598
 protein coding gene Chr19:6505420-6537061 (-)
WSB/EiJ MGP_WSBEiJ_G0024110
 protein coding gene Chr19:7201722-7235049 (-)



Homology
more
  • Human Ortholog
    MYRF, myelin regulatory factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYRF, myelin regulatory factor
  • Synonyms
    11orf9, C11orf9, CUGS, MMERV, MRF, Ndt80, pqn-47
  • Links
    NCBI Gene ID: 745
    neXtProt AC: NX_Q9Y2G1
    UniProt: Q9Y2G1

  • Chr Location
    11q12.2; chr11:61752636-61788518 (+)  GRCh38
Human Diseases
more
  • Diseases
    5 with human MYRF associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 3 alleles in 4 genetic backgrounds
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in oligodendrocytes exhibit postnatal lethality, ataxia and reduced myelination. Mice homozygous for a conditional allele activated in the eye exhibit retinal degeneration preferentially affecting cones.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    745
  • Tissues
    8
  • cDNA Data
    40
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036098 Ensembl Gene Model | MGI Sequence Detail 32477 C57BL/6J ±  kb
    transcript ENSMUST00000088013 Ensembl | MGI Sequence Detail 5674 Not Applicable  
    polypeptide ENSMUSP00000085329 Ensembl | MGI Sequence Detail 1138 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      cDNA 40
      Primer pair 3

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2686650
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 19
      Gene Ontology 9
      Phenotypes 31
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:344574 Rawlings-Mortimer F, et al., DUSP15 expression is reduced in the hippocampus of Myrf knock-out mice but attention and object recognition memory remain intact. PLoS One. 2023;18(2):e0281264
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory