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Prdm6 Gene Detail
Summary
  • Symbol
    Prdm6
  • Name
    PR domain containing 6
  • Synonyms
    LOC225518, PRISM
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684938
    NCBI Gene: 225518
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:53597027-53708976 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 29.04 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    725 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684938
 protein coding gene Chr18:53596655-53708979 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024436
 protein coding gene Chr18:52646742-52759994 (+)
A/J MGP_AJ_G0024402
 protein coding gene Chr18:50608666-50712247 (+)
AKR/J MGP_AKRJ_G0024372
 protein coding gene Chr18:52019520-52127911 (+)
BALB/cJ MGP_BALBcJ_G0024402
 protein coding gene Chr18:50794924-50898469 (+)
C3H/HeJ MGP_C3HHeJ_G0024169
 protein coding gene Chr18:52161925-52268112 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024848
 protein coding gene Chr18:54402526-54515447 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022280
 protein coding gene Chr18:50378069-50480434 (+)
CAST/EiJ MGP_CASTEiJ_G0023643
 protein coding gene Chr18:52138426-52255256 (+)
CBA/J MGP_CBAJ_G0024139
 protein coding gene Chr18:56014396-56130277 (+)
DBA/2J MGP_DBA2J_G0024269
 protein coding gene Chr18:50310434-50423615 (+)
FVB/NJ MGP_FVBNJ_G0024236
 protein coding gene Chr18:49737608-49840936 (+)
LP/J MGP_LPJ_G0024354
 protein coding gene Chr18:52666144-52773065 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024266
 protein coding gene Chr18:57749776-57895599 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024895
 protein coding gene Chr18:52053047-52163135 (+)
PWK/PhJ MGP_PWKPhJ_G0023387
 protein coding gene Chr18:50326347-50433285 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023193
 protein coding gene Chr18:52224027-52331737 (+)
WSB/EiJ MGP_WSBEiJ_G0023706
 protein coding gene Chr18:51974674-52092730 (+)



Homology
more
  • Human Ortholog
    PRDM6, PR/SET domain 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRDM6, PR/SET domain 6
  • Synonyms
    KMT8C, PDA3, PRISM
  • Links
    NCBI Gene ID: 93166
    neXtProt AC: NX_Q9NQX0
    UniProt: Q9NQX0

  • Chr Location
    5q23.2; chr5:123089241-123194266 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PRDM6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    3 images
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit cardiovascular development defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    781
  • Tissues
    48
  • cDNA Data
    13
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 225518 NCBI Gene Model | MGI Sequence Detail 111950 C57BL/6J ±  kb
    transcript NM_001033281 RefSeq | MGI Sequence Detail 2601 C57BL/6  
    polypeptide Q3UZD5 UniProt | EBI | MGI Sequence Detail 596 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 13
      Primer pair 2
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 8
      Gene Ontology 10
      Phenotypes 5
    • Earliest
      J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
    • Latest
      J:334529 Zou M, et al., Prdm6 drives ductus arteriosus closure by promoting ductus arteriosus smooth muscle cell identity and contractility. JCI Insight. 2023 Mar 8;8(5)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory