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Tbpl2 Gene Detail
Summary
  • Symbol
    Tbpl2
  • Name
    TATA box binding protein like 2
  • Synonyms
    LOC227606, Trf3
Location &
Maps
more
  • Sequence Map
    Chr2:23961733-23986607 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 16.14 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    631 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684058
 protein coding gene Chr2:23961378-23986607 (-)
129S1/SvImJ ENSMUSG00200051753
 protein coding gene Chr2:20945656-20970531 (-)
A/J ENSMUSG00195048439
 protein coding gene Chr2:21041736-21066689 (-)
AKR/J ENSMUSG00220050436
 protein coding gene Chr2:21159525-21184471 (-)
BALB/cJ ENSMUSG00180053266
 protein coding gene Chr2:21046964-21071844 (-)
C3H/HeJ ENSMUSG00175053499
 protein coding gene Chr2:21011434-21036314 (-)
C57BL/6NJ ENSMUSG00215046311
 protein coding gene Chr2:21069878-21094755 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023231
 protein coding gene Chr2:19967970-19987107 (-)
CAST/EiJ ENSTCUG00005050611
 protein coding gene Chr2:20772915-20797802 (-)
CBA/J ENSMUSG00210016999
 protein coding gene Chr2:21050447-21075324 (-)
DBA/2J ENSMUSG00185051590
 protein coding gene Chr2:20956040-20980986 (-)
FVB/NJ ENSMUSG00205049902
 protein coding gene Chr2:20809211-20834173 (-)
JF1/MsJ ENSUMUG00000053456
 protein coding gene Chr2:20853952-20879001 (-)
LP/J ENSMUSG00230044292
 protein coding gene Chr2:22881678-22906551 (-)
NOD/ShiLtJ ENSMUSG00190052695
 protein coding gene Chr2:21041766-21066637 (-)
NZO/HlLtJ ENSMUSG00225009132
 protein coding gene Chr2:30632335-30657214 (-)
PWK/PhJ ENSLUMG00010038973
 protein coding gene Chr2:20959151-20984131 (-)
SPRET/EiJ ENSMSPG00010030006
 protein coding gene Chr2:21643605-21670024 (-)
WSB/EiJ ENSIUOG00005052493
 protein coding gene Chr2:20916514-20941476 (-)



Homology
more
  • Human Ortholog
    TBPL2, TATA-box binding protein like 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TBPL2, TATA-box binding protein like 2
  • Synonyms
    TBP2, TRF3
  • Links
    NCBI Gene ID: 387332
    UniProt: Q6SJ96

  • Chr Location
    14q22.3; chr14:55414210-55456726 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Female mice homozygous for a knock-out allele exhibit infertility due to impaired folliculogenesis before or during secondary follicle development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    766
  • Tissues
    130
  • cDNA Data
    4
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061809 Ensembl Gene Model | MGI Sequence Detail 24875 C57BL/6J ±  kb
    transcript ENSMUST00000080453 Ensembl | MGI Sequence Detail 1379 Not Applicable  
    polypeptide ENSMUSP00000079309 Ensembl | MGI Sequence Detail 350 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 5
      Primer pair 3
      Antibodies 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2685194
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 4
      Gene Ontology 10
      Phenotypes 6
    • Earliest
      J:87288 Persengiev SP, et al., TRF3, a TATA-box-binding protein-related factor, is vertebrate-specific and widely expressed. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14887-91
    • Latest
      J:302834 Yu C, et al., TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage. Nat Commun. 2020 Dec 22;11(1):6439
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory