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Ric8b Gene Detail
Summary
  • Symbol
    Ric8b
  • Name
    RIC8 guanine nucleotide exchange factor B
  • Synonyms
    MGC:58970, Ric-8, Ric-8b
  • Feature Type
    protein coding gene
  • IDs
    MGI:2682307
    NCBI Gene: 237422
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:84753480-84854201 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 41.63 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1888 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2682307
 protein coding gene Chr10:84753136-84854201 (+)
129S1/SvImJ ENSMUSG00200049553
 protein coding gene Chr10:81244791-81343631 (+)
A/J ENSMUSG00195048688
 protein coding gene Chr10:81689334-81788134 (+)
AKR/J ENSMUSG00220038814
 protein coding gene Chr10:81291704-81390504 (+)
BALB/cJ ENSMUSG00180051540
 protein coding gene Chr10:81692472-81791280 (+)
C3H/HeJ ENSMUSG00175043943
 protein coding gene Chr10:81568393-81667184 (+)
C57BL/6NJ ENSMUSG00215049920
 protein coding gene Chr10:81242058-81340894 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015679
 protein coding gene Chr10:78701231-78799949 (+)
CAST/EiJ ENSTCUG00005048481
 protein coding gene Chr10:81010990-81110013 (+)
CBA/J ENSMUSG00210042054
 protein coding gene Chr10:81419125-81517928 (+)
DBA/2J ENSMUSG00185052673
 protein coding gene Chr10:81628628-81727425 (+)
FVB/NJ ENSMUSG00205032715
 protein coding gene Chr10:81346271-81445068 (+)
JF1/MsJ ENSUMUG00000014911
 protein coding gene Chr10:83001401-83107809 (+)
LP/J ENSMUSG00230014310
 protein coding gene Chr10:83530902-83629697 (+)
NOD/ShiLtJ ENSMUSG00190051128
 protein coding gene Chr10:81675097-81773895 (+)
NZO/HlLtJ ENSMUSG00225048988
 protein coding gene Chr10:87798328-87897121 (+)
PWK/PhJ ENSLUMG00010049527
 protein coding gene Chr10:81300493-81399390 (+)
SPRET/EiJ ENSMSPG00010027599
 protein coding gene Chr10:82713317-82811844 (+)
WSB/EiJ ENSIUOG00005049256
 protein coding gene Chr10:81378701-81477506 (+)



Homology
more
  • Human Ortholog
    RIC8B, RIC8 guanine nucleotide exchange factor B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RIC8B, RIC8 guanine nucleotide exchange factor B
  • Synonyms
    hSyn, RIC8
  • Links
    NCBI Gene ID: 55188
    UniProt: Q9NVN3

  • Chr Location
    12q23.3; chr12:106774621-106889316 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    704
  • Tissues
    58
  • cDNA Data
    45
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035620 Ensembl Gene Model | MGI Sequence Detail 100722 C57BL/6J ±  kb
    transcript ENSMUST00000038523 Ensembl | MGI Sequence Detail 3069 Not Applicable  
    polypeptide ENSMUSP00000046981 Ensembl | MGI Sequence Detail 560 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      cDNA 45
      Primer pair 4
      Other 1
      Antibodies 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 2
      Gene Ontology 11
      Phenotypes 23
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:366442 Tsisanova E, et al., The ric-8b protein (resistance to inhibitors of cholinesterase 8b) is key to preserving contractile function in the adult heart. J Biol Chem. 2024 Jul;300(7):107470
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory