About   Help   FAQ
Plekhg6 Gene Detail
Summary
  • Symbol
    Plekhg6
  • Name
    pleckstrin homology and RhoGEF domain containing G6
  • Synonyms
    LOC213522, MGC:30363
  • Feature Type
    protein coding gene
  • IDs
    MGI:2682298
    NCBI Gene: 213522
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:125339623-125357756 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 59.32 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    579 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2682298
 protein coding gene Chr6:125339614-125358578 (-)
129S1/SvImJ ENSMUSG00200045764
 protein coding gene Chr6:122401021-122419151 (-)
A/J ENSMUSG00195044596
 protein coding gene Chr6:121846634-121865027 (-)
AKR/J ENSMUSG00220021096
 protein coding gene Chr6:120708256-120726653 (-)
BALB/cJ ENSMUSG00180046619
 protein coding gene Chr6:122185311-122203708 (-)
C3H/HeJ ENSMUSG00175031348
 protein coding gene Chr6:121847084-121865480 (-)
C57BL/6NJ ENSMUSG00215044665
 protein coding gene Chr6:122164791-122182928 (-)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005048874
 protein coding gene Chr6:122039618-122057900 (-)
CBA/J ENSMUSG00210044280
 protein coding gene Chr6:121885680-121904079 (-)
DBA/2J ENSMUSG00185040961
 protein coding gene Chr6:122585288-122603686 (-)
FVB/NJ ENSMUSG00205032335
 protein coding gene Chr6:121300101-121318499 (-)
JF1/MsJ ENSUMUG00000041397
 protein coding gene Chr6:121002945-121021426 (-)
LP/J ENSMUSG00230042924
 protein coding gene Chr6:123782164-123800564 (-)
NOD/ShiLtJ ENSMUSG00190049501
 protein coding gene Chr6:121556868-121575264 (-)
NZO/HlLtJ ENSMUSG00225015462
 protein coding gene Chr6:125812941-125831336 (-)
PWK/PhJ ENSLUMG00010047427
 protein coding gene Chr6:120261500-120279877 (-)
SPRET/EiJ ENSMSPG00010030990
 protein coding gene Chr6:123113079-123130698 (-)
WSB/EiJ ENSIUOG00005036959
 protein coding gene Chr6:122271463-122289587 (-)



Homology
more
  • Human Ortholog
    PLEKHG6, pleckstrin homology and RhoGEF domain containing G6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLEKHG6, pleckstrin homology and RhoGEF domain containing G6
  • Synonyms
    ARHGEF46, MyoGEF
  • Links
    NCBI Gene ID: 55200
    UniProt: Q3KR16

  • Chr Location
    12p13.31; chr12:6310225-6328934 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PLEKHG6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    603
  • Tissues
    5
  • cDNA Data
    15
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038167 Ensembl Gene Model | MGI Sequence Detail 18134 C57BL/6J ±  kb
transcript ENSMUST00000042647 Ensembl | MGI Sequence Detail 3299 Not Applicable  
polypeptide ENSMUSP00000037004 Ensembl | MGI Sequence Detail 787 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 3
Other
Accession IDs
less
MGI:2685001
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 3
  • Earliest
    J:84356 Yoshizawa M, et al., Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain. Gene Expr Patterns. 2003 Jun;3(3):375-81
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory