Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Ticam1Lps2 Name: TIR domain containing adaptor molecule 1; lipopolysaccharide 2 MGI ID: MGI:2679794 Synonyms: Lps, Lps2, Lps2-, Ticam1-, Ticam1M1Btlr, TRIF-, TrifLps2, Trifm Gene: Ticam1  Location: Chr17:56576462-56583767 bp, - strand  Genetic Position: Chr17, 29.24 cM Alliance: Ticam1Lps2 page

Decreased susceptibility to induced colitis in Ticam1Lps2/Ticam1Lps2 mice Show the 1 phenotype image(s) involving this allele.

Strain of Origin:	C57BL/6J
Project Collection:	Beutler Mutagenetix

Allele Type:    Chemically induced (ENU) (Not Specified) Mutation:    Intragenic deletion   Mutation details: ENU mutagenesis induced the deletion of a single guanine within codon 708, resulting in a frameshift mutation. The mutation was predicted to replace 24 C-terminal residues with 11 unrelated residues. The mutation was initially detected by screening macrophages for their competence to respond to LPS. (J:84896, J:86521) Inheritance:    Codominant

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ticam1 Mutation:	53 strains or lines available

Original:	J:86521 Hoebe K, et al., Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening. J Endotoxin Res. 2003;9(4):250-5
All:	287 reference(s)