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Thoc6 Gene Detail
Summary
  • Symbol
    Thoc6
  • Name
    THO complex 6
  • Synonyms
    F830014G06Rik, Wdr58
  • Feature Type
    protein coding gene
  • IDs
    MGI:2677480
    NCBI Gene: 386612
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:23887588-23892856 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 17, 11.97 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    20 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2677480
protein coding gene Chr17:23887588-23892891 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023261
protein coding gene Chr17:22582519-22589257 (-)
A/J MGP_AJ_G0023221
protein coding gene Chr17:21933345-21939512 (-)
AKR/J MGP_AKRJ_G0023191
protein coding gene Chr17:22010617-22015850 (-)
BALB/cJ MGP_BALBcJ_G0023226
protein coding gene Chr17:22148648-22153944 (-)
C3H/HeJ MGP_C3HHeJ_G0022986
protein coding gene Chr17:22371419-22377354 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023669
protein coding gene Chr17:23564480-23570755 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021150
protein coding gene Chr17:19503519-19508546 (-)
CAST/EiJ MGP_CASTEiJ_G0022492
protein coding gene Chr17:22205133-22210205 (-)
CBA/J MGP_CBAJ_G0022962
protein coding gene Chr17:24375998-24381131 (-)
DBA/2J MGP_DBA2J_G0023094
protein coding gene Chr17:21562689-21567810 (-)
FVB/NJ MGP_FVBNJ_G0023061
protein coding gene Chr17:21287437-21292462 (-)
LP/J MGP_LPJ_G0023168
protein coding gene Chr17:22842198-22847335 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023080
protein coding gene Chr17:24138541-24143637 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023708
protein coding gene Chr17:22302539-22309130 (-)
PWK/PhJ MGP_PWKPhJ_G0022240
protein coding gene Chr17:20347548-20352864 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022060
protein coding gene Chr17:20327844-20332985 (-)
WSB/EiJ MGP_WSBEiJ_G0022555
protein coding gene Chr17:22358201-22364318 (-)



Homology
more
  • Human Ortholog
    THOC6, THO complex subunit 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    THOC6, THO complex subunit 6
  • Synonyms
    fSAP35, MMRFCGU, WDR58
  • Links
    NCBI Gene ID: 79228
    neXtProt AC: NX_Q86W42
    UniProt: Q86W42

  • Chr Location
    16p13.3; chr16:3024027-3027755 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with biallelic loss of function are embryonic lethal by E11.5. Embryos are smaller, show developmental delay by E9.5, and show thinner epithelium in the telencephalic vesicles.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041319 Ensembl Gene Model | MGI Sequence Detail 5269 C57BL/6J ±  kb
    transcript ENSMUST00000115490 Ensembl | MGI Sequence Detail 1431 Not Applicable  
    polypeptide ENSMUSP00000111153 Ensembl | MGI Sequence Detail 341 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      cDNA 46

      Microarray probesets 3
    References
    more
    • Summaries
      All 28
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 7
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345604 Werren EA, et al., TREX tetramer disruption alters RNA processing necessary for corticogenesis in THOC6 Intellectual Disability Syndrome. Nat Commun. 2024 Feb 22;15(1):1640

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory