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Sipa1l2 Gene Detail
Summary
  • Symbol
    Sipa1l2
  • Name
    signal-induced proliferation-associated 1 like 2
  • Synonyms
    mKIAA1389
  • Feature Type
    protein coding gene
  • IDs
    MGI:2676970
    NCBI Gene: 244668
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:126144802-126296547 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 73.63 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1974 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2676970
protein coding gene Chr8:126144802-126296602 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034286
protein coding gene Chr8:129182712-129293503 (-)
A/J MGP_AJ_G0034266
protein coding gene Chr8:123803304-123904766 (-)
AKR/J MGP_AKRJ_G0034193
protein coding gene Chr8:127387810-127463286 (-)
BALB/cJ MGP_BALBcJ_G0034259
protein coding gene Chr8:123988150-124067070 (-)
C3H/HeJ MGP_C3HHeJ_G0033970
protein coding gene Chr8:128030000-128136001 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034779
protein coding gene Chr8:133485061-133561929 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031720
protein coding gene Chr8:116557313-116632468 (-)
CAST/EiJ MGP_CASTEiJ_G0033297
protein coding gene Chr8:128151547-128333352 (-)
CBA/J MGP_CBAJ_G0033943
protein coding gene Chr8:138394200-138479428 (-)
DBA/2J MGP_DBA2J_G0034099
protein coding gene Chr8:122973433-123050667 (-)
FVB/NJ MGP_FVBNJ_G0034043
protein coding gene Chr8:122160815-122236250 (-)
LP/J MGP_LPJ_G0034188
protein coding gene Chr8:129339930-129415495 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034090
protein coding gene Chr8:140432385-140514617 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034798
protein coding gene Chr8:127634041-127711901 (-)
PWK/PhJ MGP_PWKPhJ_G0032999
protein coding gene Chr8:122710278-122887612 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032838
protein coding gene Chr8:126223483-126400024 (-)
WSB/EiJ MGP_WSBEiJ_G0033414
protein coding gene Chr8:128349688-128436299 (-)



Homology
more
  • Human Ortholog
    SIPA1L2, signal induced proliferation associated 1 like 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SIPA1L2, signal induced proliferation associated 1 like 2
  • Synonyms
    SPAL2, SPAR2
  • Links
    NCBI Gene ID: 57568
    neXtProt AC: NX_Q9P2F8
    UniProt: Q9P2F8

  • Chr Location
    1q42.2; chr1:232397965-232630571 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout results in neurological deficits relating to spatial pattern separation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000001995 Ensembl Gene Model | MGI Sequence Detail 151746 C57BL/6J ±  kb
transcript ENSMUST00000212987 Ensembl | MGI Sequence Detail 6690 Not Applicable  
polypeptide ENSMUSP00000148536 Ensembl | MGI Sequence Detail 1722 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 78
    cDNA 78

    Microarray probesets 3
References
more
  • Summaries
    All 32
    Developmental Gene Expression 4
    Gene Ontology 2
    Phenotypes 6
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory