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Mir125b-1 Gene Detail
Summary
  • Symbol
    Mir125b-1
  • Name
    microRNA 125b-1
  • Synonyms
    Mirn125b, Mirn125b-1, mmu-mir-125b-1
  • Feature Type
    miRNA gene
  • IDs
    MGI:2676810
    NCBI Gene: 387236
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:41493222-41493298 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 9, 23.41 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    22 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2676810
miRNA gene Chr9:41493222-41493298 (+)
129S1/SvImJ MGP_129S1SvImJ_G0009195
miRNA gene Chr9:39880957-39881033 (+)
A/J MGP_AJ_G0009175
miRNA gene Chr9:38837657-38837733 (+)
AKR/J MGP_AKRJ_G0009165
miRNA gene Chr9:39569481-39569557 (+)
BALB/cJ MGP_BALBcJ_G0009160
miRNA gene Chr9:38570775-38570851 (+)
C3H/HeJ MGP_C3HHeJ_G0009100
miRNA gene Chr9:40087784-40087860 (+)
C57BL/6NJ MGP_C57BL6NJ_G0009402
miRNA gene Chr9:41134791-41134867 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0008261
miRNA gene Chr9:38458432-38458508 (+)
CAST/EiJ MGP_CASTEiJ_G0008933
miRNA gene Chr9:39852157-39852233 (+)
CBA/J MGP_CBAJ_G0009068
miRNA gene Chr9:42574593-42574669 (+)
DBA/2J MGP_DBA2J_G0009099
miRNA gene Chr9:38756771-38756847 (+)
FVB/NJ MGP_FVBNJ_G0009115
miRNA gene Chr9:37991993-37992069 (+)
LP/J MGP_LPJ_G0009193
miRNA gene Chr9:40152343-40152419 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0009081
miRNA gene Chr9:44598199-44598275 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0009371
miRNA gene Chr9:39501729-39501805 (+)
PWK/PhJ MGP_PWKPhJ_G0008858
miRNA gene Chr9:38584180-38584256 (+)
SPRET/EiJ MGP_SPRETEiJ_G0008699
miRNA gene Chr9:39729857-39729933 (+)
WSB/EiJ MGP_WSBEiJ_G0009027
miRNA gene Chr9:39528326-39528402 (+)



Homology
more
  • Human Ortholog
    MIR125B1, microRNA 125b-1
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MIR125B1, microRNA 125b-1
  • Synonyms
    mir-125b-1, MIRN125B1
  • Links
    NCBI Gene ID: 406911

  • Chr Location
    chr11:122099757-122099844 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from multigenic genotypes
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • Literature Summary
Sequences &
Gene Models
less
  • All Sequences
  • RefSeq
Representative SequencesLengthStrain/SpeciesFlank
genomic 387236 NCBI Gene Model | MGI Sequence Detail 77 C57BL/6J ±  kb
transcript NR_029822 RefSeq | MGI Sequence Detail 77 C57BL/6  
For the selected sequence
Molecular
Reagents
less
  • All nucleic 10
    Primer pair 3
    Other 7
Other Database
Links
less
miRBase MI0000725
References
more
  • Summaries
    All 62
    Developmental Gene Expression 15
    Gene Ontology 10
    Phenotypes 3
  • Earliest
    J:84907 Lagos-Quintana M, et al., Identification of tissue-specific microRNAs from mouse. Curr Biol. 2002 Apr 30;12(9):735-9
  • Latest
    J:345194 Zhao H, et al., Hyperphosphorylation of Tau Due to the Interference of Protein Phosphatase Methylesterase-1 Overexpression by MiR-125b-5p in Melatonin Receptor Knockout Mice. Int J Mol Sci. 2021 Oct 31;22(21)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory