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Il17f Gene Detail
Summary
  • Symbol
    Il17f
  • Name
    interleukin 17F
  • Feature Type
    protein coding gene
  • IDs
    MGI:2676631
    NCBI Gene: 257630
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:20847370-20855498 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 6.49 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    127 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2676631
 protein coding gene Chr1:20847370-20860841 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015871
 protein coding gene Chr1:18402595-18415991 (-)
A/J MGP_AJ_G0015852
 protein coding gene Chr1:18183966-18197303 (-)
AKR/J MGP_AKRJ_G0015811
 protein coding gene Chr1:18216103-18229445 (-)
BALB/cJ MGP_BALBcJ_G0015808
 protein coding gene Chr1:17877131-17890468 (-)
C3H/HeJ MGP_C3HHeJ_G0015642
 protein coding gene Chr1:18240186-18254608 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016262
 protein coding gene Chr1:19268380-19281776 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013983
 protein coding gene Chr1:16320856-16333708 (-)
CAST/EiJ MGP_CASTEiJ_G0015223
 protein coding gene Chr1:18331802-18339368 (-)
CBA/J MGP_CBAJ_G0015615
 protein coding gene Chr1:19704851-19718191 (-)
DBA/2J MGP_DBA2J_G0015714
 protein coding gene Chr1:17677195-17690476 (-)
FVB/NJ MGP_FVBNJ_G0015719
 protein coding gene Chr1:17441080-17454349 (-)
LP/J MGP_LPJ_G0015786
 protein coding gene Chr1:18626861-18640798 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015737
 protein coding gene Chr1:20658883-20672227 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016309
 protein coding gene Chr1:18190638-18204006 (-)
PWK/PhJ MGP_PWKPhJ_G0015007
 protein coding gene Chr1:17419767-17433387 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014788
 protein coding gene Chr1:18289545-18304813 (-)
WSB/EiJ MGP_WSBEiJ_G0015286
 protein coding gene Chr1:18123943-18138575 (-)



Homology
more
  • Human Ortholog
    IL17F, interleukin 17F
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL17F, interleukin 17F
  • Synonyms
    CANDF6, IL17A, IL-17F, ML1, ML-1
  • Links
    NCBI Gene ID: 112744
    neXtProt AC: NX_Q96PD4
    UniProt: Q96PD4

  • Chr Location
    6p12.2; chr6:52236681-52245689 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human IL17F associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 5 alleles in 3 genetic backgrounds
    12 phenotypes from multigenic genotypes
    84 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele exhibit increased susceptibility to oral bacterial infection while mice homozygous for another null allele exhibit decreased susceptibility to experimental models of colitis and CNS inflammation but have enhanced inflammatory responses to a chronic asthma model.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    4
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 257630 NCBI Gene Model | MGI Sequence Detail 8129 C57BL/6J ±  kb
    transcript NM_145856 RefSeq | MGI Sequence Detail 1178 Not Specified  
    polypeptide Q7TNI7 UniProt | EBI | MGI Sequence Detail 161 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 4
      cDNA 4

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2138720
    References
    more
    • Summaries
      All 132
      Developmental Gene Expression 1
      Gene Ontology 10
      Phenotypes 84
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:342395 Sinton MC, et al., IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic murine Trypanosoma brucei infection. Nat Commun. 2023 Nov 3;14(1):7070
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory