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Wapl Gene Detail
Summary
  • Symbol
    Wapl
  • Name
    WAPL cohesin release factor
  • Synonyms
    A530089A20Rik, mKIAA0261, Wapal
  • Feature Type
    protein coding gene
  • IDs
    MGI:2675859
    NCBI Gene: 218914
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:34395885-34469940 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 20.84 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    221 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2675859
 protein coding gene Chr14:34394086-34469940 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021179
 protein coding gene Chr14:28039731-28111318 (+)
A/J MGP_AJ_G0021127
 protein coding gene Chr14:26971278-27040691 (+)
AKR/J MGP_AKRJ_G0021104
 protein coding gene Chr14:28151791-28227064 (+)
BALB/cJ MGP_BALBcJ_G0021131
 protein coding gene Chr14:27142000-27214356 (+)
C3H/HeJ MGP_C3HHeJ_G0020914
 protein coding gene Chr14:28086517-28164842 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021563
 protein coding gene Chr14:29113753-29194025 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019125
 protein coding gene Chr14:26974199-27040811 (+)
CAST/EiJ MGP_CASTEiJ_G0020439
 protein coding gene Chr14:27895378-27971794 (+)
CBA/J MGP_CBAJ_G0020880
 protein coding gene Chr14:30186207-30264355 (+)
DBA/2J MGP_DBA2J_G0021003
 protein coding gene Chr14:26997535-27063144 (+)
FVB/NJ MGP_FVBNJ_G0020987
 protein coding gene Chr14:26955961-27030602 (+)
LP/J MGP_LPJ_G0021072
 protein coding gene Chr14:28368207-28439887 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021013
 protein coding gene Chr14:29303918-29400549 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021596
 protein coding gene Chr14:27996242-28078922 (+)
PWK/PhJ MGP_PWKPhJ_G0020187
 protein coding gene Chr14:26480470-26552330 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020011
 protein coding gene Chr14:27592963-27662227 (+)
WSB/EiJ MGP_WSBEiJ_G0020494
 protein coding gene Chr14:28039192-28120236 (+)



Homology
more
  • Human Ortholog
    WAPL, WAPL cohesin release factor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WAPL, WAPL cohesin release factor
  • Synonyms
    FOE, KIAA0261, WAPAL
  • Links
    NCBI Gene ID: 23063
    neXtProt AC: NX_Q7Z5K2
    UniProt: Q7Z5K2

  • Chr Location
    10q23.2; chr10:86435256-86521792 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 4 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit prenatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    802
  • Tissues
    96
  • cDNA Data
    13
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041408 Ensembl Gene Model | MGI Sequence Detail 74056 C57BL/6J ±  kb
transcript ENSMUST00000169910 Ensembl | MGI Sequence Detail 4066 Not Applicable  
polypeptide ENSMUSP00000130547 Ensembl | MGI Sequence Detail 1200 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 9
Other
Accession IDs
less
MGI:2443602
References
more
  • Summaries
    All 44
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 16
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:337208 Kiefer L, et al., WAPL functions as a rheostat of Protocadherin isoform diversity that controls neural wiring. Science. 2023 Jun 23;380(6651):eadf8440
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory