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Arhgef17 Gene Detail
Summary
  • Symbol
    Arhgef17
  • Name
    Rho guanine nucleotide exchange factor 17
  • Synonyms
    mKIAA0337
  • Feature Type
    protein coding gene
  • IDs
    MGI:2673002
    NCBI Gene: 207212
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:100518959-100581314 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 54.45 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    485 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2673002
 protein coding gene Chr7:100518953-100581368 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032578
 protein coding gene Chr7:103792711-103856279 (-)
A/J MGP_AJ_G0032552
 protein coding gene Chr7:101161669-101221994 (-)
AKR/J MGP_AKRJ_G0032488
 protein coding gene Chr7:103569544-103632073 (-)
BALB/cJ MGP_BALBcJ_G0032563
 protein coding gene Chr7:100849339-100909440 (-)
C3H/HeJ MGP_C3HHeJ_G0032278
 protein coding gene Chr7:103963578-104024005 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033061
 protein coding gene Chr7:107721536-107790341 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030055
 protein coding gene Chr7:103549159-103607771 (-)
CAST/EiJ MGP_CASTEiJ_G0031605
 protein coding gene Chr7:95519857-95585999 (-)
CBA/J MGP_CBAJ_G0032245
 protein coding gene Chr7:111437069-111503266 (-)
DBA/2J MGP_DBA2J_G0032396
 protein coding gene Chr7:99491773-99554600 (-)
FVB/NJ MGP_FVBNJ_G0032353
 protein coding gene Chr7:99276835-99336266 (-)
LP/J MGP_LPJ_G0032486
 protein coding gene Chr7:105132152-105194974 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032386
 protein coding gene Chr7:112813852-112877301 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033083
 protein coding gene Chr7:102836196-102901475 (-)
PWK/PhJ MGP_PWKPhJ_G0031323
 protein coding gene Chr7:92611346-92674311 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031166
 protein coding gene Chr7:90145558-90212464 (-)
WSB/EiJ MGP_WSBEiJ_G0031722
 protein coding gene Chr7:103544017-103606041 (-)



Homology
more
  • Human Ortholog
    ARHGEF17, Rho guanine nucleotide exchange factor 17
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGEF17, Rho guanine nucleotide exchange factor 17
  • Synonyms
    p164-RhoGEF, P164RHOGEF, RHOGEF17, TEM4
  • Links
    NCBI Gene ID: 9828
    neXtProt AC: NX_Q96PE2
    UniProt: Q96PE2

  • Chr Location
    11q13.4; chr11:73308276-73369388 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    4
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Arhgef17
  • Incidental Mutations
    Mutagenetix , APF
  • Find Mice (IMSR)
    58 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    100
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032875 Ensembl Gene Model | MGI Sequence Detail 62356 C57BL/6J ±  kb
transcript ENSMUST00000107032 Ensembl | MGI Sequence Detail 10190 Not Applicable  
polypeptide ENSMUSP00000102647 Ensembl | MGI Sequence Detail 2057 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000004252 Rho guanine nucleotide exchange factor 17
    (term hierarchy)
  • InterPro Domains
    IPR000219 Dbl homology (DH) domain
    IPR035899 Dbl homology (DH) domain superfamily
    IPR011993 PH-like domain superfamily
    IPR039919 Rho guanine nucleotide exchange factor 10/17
    IPR036322 WD40-repeat-containing domain superfamily
    IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Molecular
Reagents
less
  • All nucleic 100
    cDNA 100

    Microarray probesets 7
Other
Accession IDs
less
MGI:2141948, MGI:2142267
References
more
  • Summaries
    All 45
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 16
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:324573 Garcia-Jimenez I, et al., Gbetagamma mediates activation of Rho guanine nucleotide exchange factor ARHGEF17 that promotes metastatic lung cancer progression. J Biol Chem. 2021 Nov 20;298(1):101440
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory