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Trim46 Gene Detail
Summary
  • Symbol
    Trim46
  • Name
    tripartite motif-containing 46
  • Synonyms
    TRIFIC
  • Feature Type
    protein coding gene
  • IDs
    MGI:2673000
    NCBI Gene: 360213
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:89141484-89153616 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 39.02 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    326 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2673000
 protein coding gene Chr3:89141476-89153655 (-)
129S1/SvImJ ENSMUSG00200039179
 protein coding gene Chr3:85996465-86008598 (-)
A/J ENSMUSG00195052970
 protein coding gene Chr3:86011368-86023552 (-)
AKR/J ENSMUSG00220045665
 protein coding gene Chr3:85965945-85978130 (-)
BALB/cJ ENSMUSG00180045631
 protein coding gene Chr3:86093282-86105415 (-)
C3H/HeJ ENSMUSG00175040929
 protein coding gene Chr3:85944007-85956191 (-)
C57BL/6NJ ENSMUSG00215045760
 protein coding gene Chr3:86384219-86396352 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025196
 protein coding gene Chr3:81959094-81971408 (-)
CAST/EiJ ENSTCUG00005041341
 protein coding gene Chr3:85459020-85471216 (-)
CBA/J ENSMUSG00210041488
 protein coding gene Chr3:86081663-86093847 (-)
DBA/2J ENSMUSG00185048968
 protein coding gene Chr3:86181776-86193908 (-)
FVB/NJ ENSMUSG00205036575
 protein coding gene Chr3:85005606-85017790 (-)
JF1/MsJ ENSUMUG00000022874
 protein coding gene Chr3:85790133-85802312 (-)
LP/J ENSMUSG00230028496
 protein coding gene Chr3:88217788-88229920 (-)
NOD/ShiLtJ ENSMUSG00190026898
 protein coding gene Chr3:86466690-86478828 (-)
NZO/HlLtJ ENSMUSG00225007597
 protein coding gene Chr3:90972967-90985150 (-)
PWK/PhJ ENSLUMG00010051542
 protein coding gene Chr3:85831603-85843780 (-)
SPRET/EiJ ENSMSPG00010048448
 protein coding gene Chr3:86693013-86705190 (-)
WSB/EiJ ENSIUOG00005048848
 protein coding gene Chr3:86488029-86500359 (-)



Homology
more
  • Human Ortholog
    TRIM46, tripartite motif containing 46
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIM46, tripartite motif containing 46
  • Synonyms
    GENEY, TRIFIC
  • Links
    NCBI Gene ID: 80128
    UniProt: Q7Z4K8

  • Chr Location
    1q22; chr1:155173787-155184971 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    10
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042766 Ensembl Gene Model | MGI Sequence Detail 12133 C57BL/6J ±  kb
transcript ENSMUST00000041022 Ensembl | MGI Sequence Detail 3122 Not Applicable  
polypeptide ENSMUSP00000036053 Ensembl | MGI Sequence Detail 759 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 2
Other
Accession IDs
less
MGI:2139686
References
more
  • Summaries
    All 42
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 8
    Phenotypes 14
  • Earliest
    J:29857 Vos HL, et al., A tightly organized, conserved gene cluster on mouse chromosome 3 (E3-F1). Mamm Genome. 1995 Nov;6(11):820-2
  • Latest
    J:357972 Melton AJ, et al., TRIM46 Is Required for Microtubule Fasciculation In Vivo But Not Axon Specification or Axon Initial Segment Formation. J Neurosci. 2024 Oct 16;44(42)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory