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Kcnv2 Gene Detail
Summary
  • Symbol
    Kcnv2
  • Name
    potassium channel, subfamily V, member 2
  • Synonyms
    KV11.1, MGC:38990
  • Feature Type
    protein coding gene
  • IDs
    MGI:2670981
    NCBI Gene: 240595
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:27299988-27314579 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 21.88 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    545 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2670981
 protein coding gene Chr19:27299461-27314579 (+)
129S1/SvImJ ENSMUSG00200020197
 protein coding gene Chr19:24016563-24031149 (+)
A/J ENSMUSG00195035085
 protein coding gene Chr19:24191973-24206568 (+)
AKR/J ENSMUSG00220018566
 protein coding gene Chr19:24232426-24247025 (+)
BALB/cJ ENSMUSG00180013322
 protein coding gene Chr19:24513331-24527922 (+)
C3H/HeJ ENSMUSG00175024089
 protein coding gene Chr19:23889709-23904301 (+)
C57BL/6NJ ENSMUSG00215025214
 protein coding gene Chr19:23930048-23944640 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022844
 protein coding gene Chr19:24379652-24394463 (+)
CAST/EiJ ENSTCUG00005018027
 protein coding gene Chr19:23768930-23783511 (+)
CBA/J ENSMUSG00210014326
 protein coding gene Chr19:24120695-24135285 (+)
DBA/2J ENSMUSG00185025790
 protein coding gene Chr19:24507424-24522015 (+)
FVB/NJ ENSMUSG00205010996
 protein coding gene Chr19:23895342-23909941 (+)
JF1/MsJ ENSUMUG00000032629
 protein coding gene Chr19:24726846-24741384 (+)
LP/J ENSMUSG00230027278
 protein coding gene Chr19:25325980-25340569 (+)
NOD/ShiLtJ ENSMUSG00190021187
 protein coding gene Chr19:23884187-23898778 (+)
NZO/HlLtJ ENSMUSG00225033397
 protein coding gene Chr19:29076837-29091429 (+)
PWK/PhJ ENSLUMG00010031354
 protein coding gene Chr19:24100967-24115440 (+)
SPRET/EiJ ENSMSPG00010034157
 protein coding gene Chr19:24057289-24071903 (+)
WSB/EiJ ENSIUOG00005026101
 protein coding gene Chr19:23616958-23631550 (+)



Homology
more
  • Human Ortholog
    KCNV2, potassium voltage-gated channel modifier subfamily V member 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNV2, potassium voltage-gated channel modifier subfamily V member 2
  • Synonyms
    CDSRR, KV11.1, Kv8.2, RCD3B
  • Links
    NCBI Gene ID: 169522
    UniProt: Q8TDN2

  • Chr Location
    9p24.2; chr9:2717510-2730037 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human KCNV2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit loss of photoreceptors with increased apoptosis and defective photopic and scotopic response.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    615
  • Tissues
    13
  • cDNA Data
    13
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000047298 Ensembl Gene Model | MGI Sequence Detail 14592 C57BL/6J ±  kb
    transcript ENSMUST00000056708 Ensembl | MGI Sequence Detail 5108 Not Applicable  
    polypeptide ENSMUSP00000055091 Ensembl | MGI Sequence Detail 562 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 14
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 5
      Gene Ontology 3
      Phenotypes 9
    • Earliest
      J:93300 Blackshaw S, et al., Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
    • Latest
      J:374738 Zarybnicky T, et al., In vivo modeling of lethal congenital contracture syndrome 1 suggests pathomechanisms in cellular stress responses. FEBS J. 2025;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory