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Crb3 Gene Detail
Summary
  • Symbol
    Crb3
  • Name
    crumbs family member 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2670904
    NCBI Gene: 224912
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:57368583-57372920 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 29.65 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    22 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2670904
 protein coding gene Chr17:57366105-57372920 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023952
 protein coding gene Chr17:58810377-58821631 (+)
A/J MGP_AJ_G0023910
 protein coding gene Chr17:57185097-57192450 (+)
AKR/J MGP_AKRJ_G0023879
 protein coding gene Chr17:57906502-57913294 (+)
BALB/cJ MGP_BALBcJ_G0023911
 protein coding gene Chr17:57023046-57030446 (+)
C3H/HeJ MGP_C3HHeJ_G0023675
 protein coding gene Chr17:58627241-58635928 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024357
 protein coding gene Chr17:61091775-61098586 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021803
 protein coding gene Chr17:53662152-53668981 (+)
CAST/EiJ MGP_CASTEiJ_G0023157
 protein coding gene Chr17:58924233-58933765 (+)
CBA/J MGP_CBAJ_G0023651
 protein coding gene Chr17:63471799-63488115 (+)
DBA/2J MGP_DBA2J_G0023779
 protein coding gene Chr17:55879504-55886967 (+)
FVB/NJ MGP_FVBNJ_G0023745
 protein coding gene Chr17:55452320-55459135 (+)
LP/J MGP_LPJ_G0023861
 protein coding gene Chr17:59489805-59515451 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023773
 protein coding gene Chr17:62929349-62937072 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024401
 protein coding gene Chr17:58268017-58274792 (+)
PWK/PhJ MGP_PWKPhJ_G0022903
 protein coding gene Chr17:55248306-55255780 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022714
 protein coding gene Chr17:55038017-55046586 (+)
WSB/EiJ MGP_WSBEiJ_G0023223
 protein coding gene Chr17:58892321-58900120 (+)



Homology
more
  • Human Ortholog
    CRB3, crumbs cell polarity complex component 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRB3, crumbs cell polarity complex component 3
  • Links
    NCBI Gene ID: 92359
    neXtProt AC: NX_Q9BUF7
    UniProt: Q9BUF7

  • Chr Location
    19p13.3; chr19:6463777-6467221 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 4 alleles in 4 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit neonatal lethality likely due to respiratory distress, abnormal pulmonary alveolus morphology, kidney cysts and abnormal small intestinal morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    787
  • Tissues
    49
  • cDNA Data
    11
  • Literature Summary
    36
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 224912 NCBI Gene Model | MGI Sequence Detail 4338 C57BL/6J ±  kb
    transcript NM_177638 RefSeq | MGI Sequence Detail 1206 C57BL/6  
    polypeptide Q8QZT4 UniProt | EBI | MGI Sequence Detail 113 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2146967, MGI:2146999
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 36
      Gene Ontology 8
      Phenotypes 10
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:336187 Barlow HR, et al., Rab11 is essential to pancreas morphogenesis, lumen formation and endocrine mass. Dev Biol. 2023 Jul;499:59-74
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory