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Prss33 Gene Detail
Summary
  • Symbol
    Prss33
  • Name
    serine protease 33
  • Synonyms
    Eos, mT6, tryptase-6
Location &
Maps
more
  • Sequence Map
    Chr17:24052321-24055030 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.08 cM, cytoband A3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    103 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2661234
 protein coding gene Chr17:24052312-24055667 (-)
129S1/SvImJ ENSMUSG00200037261
 protein coding gene Chr17:19471458-19473854 (-)
A/J ENSMUSG00195036506
 protein coding gene Chr17:20490228-20492624 (-)
AKR/J ENSMUSG00220022851
 protein coding gene Chr17:19550773-19553169 (-)
BALB/cJ ENSMUSG00180015966
 protein coding gene Chr17:19773306-19775702 (-)
C3H/HeJ ENSMUSG00175033022
 protein coding gene Chr17:19557830-19560226 (-)
C57BL/6NJ ENSMUSG00215040660
 protein coding gene Chr17:19560088-19562484 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021163
 protein coding gene Chr17:19662813-19665535 (-)
CAST/EiJ ENSTCUG00005022724
 protein coding gene Chr17:20135811-20138207 (-)
CBA/J ENSMUSG00210034719
 protein coding gene Chr17:19396643-19399039 (-)
DBA/2J ENSMUSG00185051791
 protein coding gene Chr17:21578636-21581032 (-)
FVB/NJ ENSMUSG00205014873
 protein coding gene Chr17:19847171-19849567 (-)
JF1/MsJ ENSUMUG00000056778
 protein coding gene Chr17:21051876-21054272 (-)
LP/J ENSMUSG00230054944
 protein coding gene Chr17:22976158-22978554 (-)
NOD/ShiLtJ ENSMUSG00190029504
 protein coding gene Chr17:19475779-19478175 (-)
NZO/HlLtJ ENSMUSG00225053008
 protein coding gene Chr17:24897775-24900171 (-)
PWK/PhJ ENSLUMG00010019687
 protein coding gene Chr17:18947503-18949899 (-)
SPRET/EiJ ENSMSPG00010035616
 protein coding gene Chr17:20304881-20307051 (-)
WSB/EiJ ENSIUOG00005036138
 protein coding gene Chr17:20224145-20226541 (-)



Homology
more
  • Human Ortholog
    PRSS33, serine protease 33
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRSS33, serine protease 33
  • Synonyms
    EOS
  • Links
    NCBI Gene ID: 260429
    UniProt: Q8NF86

  • Chr Location
    16p13.3; chr16:2783926-2787948 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    637
  • Tissues
    25
  • cDNA Data
    6
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000049620 Ensembl Gene Model | MGI Sequence Detail 2710 C57BL/6J ±  kb
    transcript ENSMUST00000059906 Ensembl | MGI Sequence Detail 1373 Not Applicable  
    polypeptide ENSMUSP00000059491 Ensembl | MGI Sequence Detail 277 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 6
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:86752 Wong GW, et al., Mouse chromosome 17A3.3 contains 13 genes that encode functional tryptic-like serine proteases with distinct tissue and cell expression patterns. J Biol Chem. 2004 Jan 23;279(4):2438-52
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory