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Cnksr2 Gene Detail
Summary
  • Symbol
    Cnksr2
  • Name
    connector enhancer of kinase suppressor of Ras 2
  • Synonyms
    Cnk2, Ksr2, mKIAA0902
  • Feature Type
    protein coding gene
  • IDs
    MGI:2661175
    NCBI Gene: 245684
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:156604432-156826290 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 72.76 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    666 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2661175
 protein coding gene ChrX:156604426-156827454 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036222
 protein coding gene ChrX:155712065-155950830 (-)
A/J MGP_AJ_G0036192
 protein coding gene ChrX:155027526-155255340 (-)
AKR/J MGP_AKRJ_G0036120
 protein coding gene ChrX:159923940-160156128 (-)
BALB/cJ MGP_BALBcJ_G0036185
 protein coding gene ChrX:153083403-153307242 (-)
C3H/HeJ MGP_C3HHeJ_G0035891
 protein coding gene ChrX:156071749-156313682 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036707
 protein coding gene ChrX:160311812-160563383 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033528
 protein coding gene ChrX:146359801-146598164 (-)
CAST/EiJ MGP_CASTEiJ_G0035179
 protein coding gene ChrX:135172241-135442636 (-)
CBA/J MGP_CBAJ_G0035866
 protein coding gene ChrX:164894441-165143504 (-)
DBA/2J MGP_DBA2J_G0036032
 protein coding gene ChrX:154000323-154224585 (-)
FVB/NJ MGP_FVBNJ_G0035963
 protein coding gene ChrX:153097932-153338071 (-)
LP/J MGP_LPJ_G0036117
 protein coding gene ChrX:156870526-157107115 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035995
 protein coding gene ChrX:173458637-173776804 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036748
 protein coding gene ChrX:155263537-155503217 (-)
PWK/PhJ MGP_PWKPhJ_G0034877
 protein coding gene ChrX:132120710-132346401 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034698
 protein coding gene ChrX:135644432-135864651 (-)
WSB/EiJ MGP_WSBEiJ_G0035314
 protein coding gene ChrX:153256105-153486693 (-)



Homology
more
  • Human Ortholog
    CNKSR2, connector enhancer of kinase suppressor of Ras 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CNKSR2, connector enhancer of kinase suppressor of Ras 2
  • Synonyms
    CNK2, KSR2, MAGUIN, MRXSHG
  • Links
    NCBI Gene ID: 22866
    neXtProt AC: NX_Q8WXI2
    UniProt: Q8WXI2

  • Chr Location
    Xp22.12; chrX:21372801-21654695 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CNKSR2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025658 Ensembl Gene Model | MGI Sequence Detail 221859 C57BL/6J ±  kb
    transcript ENSMUST00000026750 Ensembl | MGI Sequence Detail 5738 Not Applicable  
    polypeptide ENSMUSP00000026750 Ensembl | MGI Sequence Detail 1032 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 17

      Microarray probesets 2
    References
    more
    • Summaries
      All 32
      Gene Ontology 6
      Phenotypes 6
    • Earliest
      J:83413 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Feb 28;10(1):35-48
    • Latest
      J:345304 Maruo T, et al., s-Afadin binds to MAGUIN/Cnksr2 and regulates the localization of the AMPA receptor and glutamatergic synaptic response in hippocampal neurons. J Biol Chem. 2023 Feb 18;299(4):103040
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory