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C1rl Gene Detail
Summary
  • Symbol
    C1rl
  • Name
    complement component 1, r subcomponent-like
  • Synonyms
    C1rl1, C1r-LP
  • Feature Type
    protein coding gene
  • IDs
    MGI:2660692
    NCBI Gene: 232371
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:124470072-124487602 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 59.16 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    540 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2660692
 protein coding gene Chr6:124470072-124487602 (+)
129S1/SvImJ ENSMUSG00200046070
 protein coding gene Chr6:121531422-121548955 (+)
A/J ENSMUSG00195046511
 protein coding gene Chr6:120989813-121007347 (+)
AKR/J ENSMUSG00220031789
 protein coding gene Chr6:119851403-119868936 (+)
BALB/cJ ENSMUSG00180047100
 protein coding gene Chr6:121328418-121345952 (+)
C3H/HeJ ENSMUSG00175038424
 protein coding gene Chr6:120989856-121007394 (+)
C57BL/6NJ ENSMUSG00215047032
 protein coding gene Chr6:121295120-121312650 (+)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005048283
 protein coding gene Chr6:121169269-121186770 (+)
CBA/J ENSMUSG00210039108
 protein coding gene Chr6:121086739-121104272 (+)
DBA/2J ENSMUSG00185037415
 protein coding gene Chr6:121728549-121746084 (+)
FVB/NJ ENSMUSG00205031482
 protein coding gene Chr6:120443210-120460742 (+)
JF1/MsJ ENSUMUG00000043057
 protein coding gene Chr6:120136507-120153965 (+)
LP/J ENSMUSG00230039514
 protein coding gene Chr6:122924587-122942117 (+)
NOD/ShiLtJ ENSMUSG00190044544
 protein coding gene Chr6:120700156-120717691 (+)
NZO/HlLtJ ENSMUSG00225015441
 protein coding gene Chr6:124823630-124841102 (+)
PWK/PhJ ENSLUMG00010046977
 protein coding gene Chr6:119402699-119420262 (+)
SPRET/EiJ ENSMSPG00010037632
 protein coding gene Chr6:122275493-122292145 (+)
WSB/EiJ ENSIUOG00005043788
 protein coding gene Chr6:121408437-121425971 (+)



Homology
more
  • Human Ortholog
    C1RL, complement C1r subcomponent like
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    C1RL, complement C1r subcomponent like
  • Synonyms
    C1RL1, C1r-LP, C1RLP, CLSPa
  • Links
    NCBI Gene ID: 51279
    UniProt: Q9NZP8

  • Chr Location
    12p13.31; chr12:7089587-7109245 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    600
  • Tissues
    3
  • cDNA Data
    23
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 232371 NCBI Gene Model | MGI Sequence Detail 17531 C57BL/6J ±  kb
    transcript NM_181344 RefSeq | MGI Sequence Detail 3010 C57BL/6  
    polypeptide Q3UZ09 UniProt | EBI | MGI Sequence Detail 482 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 23

      Microarray probesets 1
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 9
    • Earliest
      J:83023 Circolo A, et al., A novel murine complement-related gene encoding a C1r-like serum protein. Mol Immunol. 2003 May;39(14):899-906
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory