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Wasf3 Gene Detail
Summary
  • Symbol
    Wasf3
  • Name
    WASP family, member 3
  • Synonyms
    Wave3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2658986
    NCBI Gene: 245880
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:146321795-146410425 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 85.23 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2584 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2658986
 protein coding gene Chr5:146317411-146410425 (+)
129S1/SvImJ ENSMUSG00200040044
 protein coding gene Chr5:140153313-140241950 (+)
A/J ENSMUSG00195043860
 protein coding gene Chr5:139649337-139738064 (+)
AKR/J ENSMUSG00220021762
 protein coding gene Chr5:138771438-138860081 (+)
BALB/cJ ENSMUSG00180031700
 protein coding gene Chr5:140042956-140131681 (+)
C3H/HeJ ENSMUSG00175042915
 protein coding gene Chr5:141969647-142058353 (+)
C57BL/6NJ ENSMUSG00215038680
 protein coding gene Chr5:139768841-139857476 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028026
 protein coding gene Chr5:139958607-140046523 (+)
CAST/EiJ ENSTCUG00005033544
 protein coding gene Chr5:139235072-139325808 (+)
CBA/J ENSMUSG00210023286
 protein coding gene Chr5:140907604-140996239 (+)
DBA/2J ENSMUSG00185036484
 protein coding gene Chr5:143772367-143861081 (+)
FVB/NJ ENSMUSG00205034773
 protein coding gene Chr5:139536498-139625171 (+)
JF1/MsJ ENSUMUG00000023598
 protein coding gene Chr5:146357369-146448844 (+)
LP/J ENSMUSG00230025332
 protein coding gene Chr5:147870285-147958909 (+)
NOD/ShiLtJ ENSMUSG00190042535
 protein coding gene Chr5:139482662-139571337 (+)
NZO/HlLtJ ENSMUSG00225008020
 protein coding gene Chr5:155483514-155572188 (+)
PWK/PhJ ENSLUMG00010018254
 protein coding gene Chr5:138638210-138729551 (+)
SPRET/EiJ ENSMSPG00010005698
 protein coding gene Chr5:141462774-141552619 (+)
WSB/EiJ ENSIUOG00005031961
 protein coding gene Chr5:142292117-142380786 (+)



Homology
more
  • Human Ortholog
    WASF3, WASP family member 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WASF3, WASP family member 3
  • Synonyms
    Brush-1, SCAR3, WAVE3
  • Links
    NCBI Gene ID: 10810
    UniProt: Q9UPY6

  • Chr Location
    13q12.13; chr13:26539139-26688948 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Mice homozygous for a knock-out allele exhibit normal platelet physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    805
  • Tissues
    42
  • cDNA Data
    17
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029636 Ensembl Gene Model | MGI Sequence Detail 88631 C57BL/6J ±  kb
transcript ENSMUST00000016143 Ensembl | MGI Sequence Detail 5196 Not Applicable  
polypeptide ENSMUSP00000016143 Ensembl | MGI Sequence Detail 501 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    Genomic 1
    cDNA 17
    Primer pair 1
    Other 1
    Antibodies 4

    Microarray probesets 5
References
more
  • Summaries
    All 44
    Developmental Gene Expression 7
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:83138 Sossey-Alaoui K, et al., Genomic organization and expression profile of the human and mouse WAVE gene family. Mamm Genome. 2003 May;14(5):314-22
  • Latest
    J:354447 Zhang Y, et al., Neurodevelopmental disorder-associated CYFIP2 regulates membraneless organelles and eIF2alpha phosphorylation via protein interactors and actin cytoskeleton. Hum Mol Genet. 2024 Sep 19;33(19):1671-1687
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory