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Shc4 Gene Detail
Summary
  • Symbol
    Shc4
  • Name
    SHC (Src homology 2 domain containing) family, member 4
  • Synonyms
    6230417E10Rik, 9930029B02Rik, LOC271849
  • Feature Type
    protein coding gene
  • IDs
    MGI:2655364
    NCBI Gene: 271849
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:125469367-125566068 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 61.76 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2647 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2655364
 protein coding gene Chr2:125469359-125566085 (-)
129S1/SvImJ ENSMUSG00200046589
 protein coding gene Chr2:122514267-122610415 (-)
A/J ENSMUSG00195030387
 protein coding gene Chr2:122545437-122641441 (-)
AKR/J ENSMUSG00220044518
 protein coding gene Chr2:122303392-122399556 (-)
BALB/cJ ENSMUSG00180048072
 protein coding gene Chr2:122332411-122428399 (-)
C3H/HeJ ENSMUSG00175037327
 protein coding gene Chr2:122828522-122920015 (-)
C57BL/6NJ ENSMUSG00215024345
 protein coding gene Chr2:122390130-122486096 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024229
 protein coding gene Chr2:118359549-118454655 (-)
CAST/EiJ ENSTCUG00005033278
 protein coding gene Chr2:121687387-121778772 (-)
CBA/J ENSMUSG00210028884
 protein coding gene Chr2:122677023-122768528 (-)
DBA/2J ENSMUSG00185030210
 protein coding gene Chr2:122331128-122422662 (-)
FVB/NJ ENSMUSG00205030233
 protein coding gene Chr2:121542729-121638932 (-)
JF1/MsJ ENSUMUG00000007590
 protein coding gene Chr2:122196350-122288083 (-)
LP/J ENSMUSG00230034613
 protein coding gene Chr2:124152756-124248889 (-)
NOD/ShiLtJ ENSMUSG00190014987
 protein coding gene Chr2:122510521-122606668 (-)
NZO/HlLtJ ENSMUSG00225002421
 protein coding gene Chr2:132058894-132155012 (-)
PWK/PhJ ENSLUMG00010047473
 protein coding gene Chr2:122093305-122184417 (-)
SPRET/EiJ ENSMSPG00010029129
 protein coding gene Chr2:124546837-124639027 (-)
WSB/EiJ ENSIUOG00005040758
 protein coding gene Chr2:122323348-122419765 (-)



Homology
more
  • Human Ortholog
    SHC4, SHC adaptor protein 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SHC4, SHC adaptor protein 4
  • Synonyms
    RaLP, SHCD
  • Links
    NCBI Gene ID: 399694
    UniProt: Q6S5L8

  • Chr Location
    15q21.1; chr15:48823741-48963919 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    793
  • Tissues
    155
  • cDNA Data
    4
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035109 Ensembl Gene Model | MGI Sequence Detail 96702 C57BL/6J ±  kb
transcript ENSMUST00000042246 Ensembl | MGI Sequence Detail 4059 Not Applicable  
polypeptide ENSMUSP00000043146 Ensembl | MGI Sequence Detail 626 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    Genomic 2
    cDNA 6
    Primer pair 1
    Other 1
    Antibodies 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:2685531
References
more
  • Summaries
    All 37
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory