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Prss53 Gene Detail
Summary
  • Symbol
    Prss53
  • Name
    serine protease 53
  • Synonyms
    BC039632
  • Feature Type
    protein coding gene
  • IDs
    MGI:2652890
    NCBI Gene: 330657
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:127485013-127490142 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.81 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    27 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2652890
 protein coding gene Chr7:127484616-127490594 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033060
 protein coding gene Chr7:132269043-132275551 (-)
A/J MGP_AJ_G0033043
 protein coding gene Chr7:128730009-128736362 (-)
AKR/J MGP_AKRJ_G0032975
 protein coding gene Chr7:132058792-132063924 (-)
BALB/cJ MGP_BALBcJ_G0033044
 protein coding gene Chr7:128382985-128388114 (-)
C3H/HeJ MGP_C3HHeJ_G0032758
 protein coding gene Chr7:131962285-131967417 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033553
 protein coding gene Chr7:137417371-137422536 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030526
 protein coding gene Chr7:129921019-129926205 (-)
CAST/EiJ MGP_CASTEiJ_G0032087
 protein coding gene Chr7:123755131-123761512 (-)
CBA/J MGP_CBAJ_G0032731
 protein coding gene Chr7:142087836-142092964 (-)
DBA/2J MGP_DBA2J_G0032883
 protein coding gene Chr7:126707291-126712504 (-)
FVB/NJ MGP_FVBNJ_G0032836
 protein coding gene Chr7:126567106-126574205 (-)
LP/J MGP_LPJ_G0032977
 protein coding gene Chr7:133740525-133745731 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032868
 protein coding gene Chr7:143157730-143162869 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033573
 protein coding gene Chr7:131048791-131053920 (-)
PWK/PhJ MGP_PWKPhJ_G0031794
 protein coding gene Chr7:119715008-119720177 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031640
 protein coding gene Chr7:117860404-117865530 (-)
WSB/EiJ MGP_WSBEiJ_G0032199
 protein coding gene Chr7:132014940-132020067 (-)



Homology
more
  • Human Ortholog
    PRSS53, serine protease 53
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRSS53, serine protease 53
  • Synonyms
    POL3S, UNQ308
  • Links
    NCBI Gene ID: 339105
    neXtProt AC: NX_Q2L4Q9
    UniProt: Q2L4Q9

  • Chr Location
    16p11.2; chr16:31083437-31089628 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000044139 Ensembl Gene Model | MGI Sequence Detail 5130 C57BL/6J ±  kb
    transcript ENSMUST00000121394 Ensembl | MGI Sequence Detail 2134 Not Applicable  
    polypeptide ENSMUSP00000112972 Ensembl | MGI Sequence Detail 552 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 3
      cDNA 3

      Microarray probesets 1
    References
    more
    • Summaries
      All 20
      Gene Ontology 3
      Phenotypes 5
    • Earliest
      J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
    • Latest
      J:322490 Mori M, et al., Polygenic control of the wavy coat of the NCT mouse: involvement of an intracisternal A particle insertional mutation of the protease, serine 53 (Prss53) gene, and a modifier gene. Mamm Genome. 2022 Jan 24;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory