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Cldn17 Gene Detail
Summary
  • Symbol
    Cldn17
  • Name
    claudin 17
  • Feature Type
    protein coding gene
  • IDs
    MGI:2652030
    NCBI Gene: 239931
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:88302695-88303866 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 51.12 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    45 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2652030
 protein coding gene Chr16:88302695-88303866 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022983
 protein coding gene Chr16:89309429-89310674 (-)
A/J MGP_AJ_G0022951
 protein coding gene Chr16:85167369-85168540 (-)
AKR/J MGP_AKRJ_G0022921
 protein coding gene Chr16:87750502-87751673 (-)
BALB/cJ MGP_BALBcJ_G0022953
 protein coding gene Chr16:85696985-85698156 (-)
C3H/HeJ MGP_C3HHeJ_G0022715
 protein coding gene Chr16:88319484-88320655 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023400
 protein coding gene Chr16:92179223-92180394 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020904
 protein coding gene Chr16:83005486-83006661 (-)
CAST/EiJ MGP_CASTEiJ_G0022237
 protein coding gene Chr16:88749384-88750553 (-)
CBA/J MGP_CBAJ_G0022684
 protein coding gene Chr16:96132867-96134038 (-)
DBA/2J MGP_DBA2J_G0022818
 protein coding gene Chr16:85097558-85098729 (-)
FVB/NJ MGP_FVBNJ_G0022793
 protein coding gene Chr16:84195232-84196403 (-)
LP/J MGP_LPJ_G0022887
 protein coding gene Chr16:88997225-88998436 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022812
 protein coding gene Chr16:100670584-100671755 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023418
 protein coding gene Chr16:88252045-88253216 (-)
PWK/PhJ MGP_PWKPhJ_G0021980
 protein coding gene Chr16:85253511-85254688 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021810
 protein coding gene Chr16:87806952-87808127 (-)
WSB/EiJ MGP_WSBEiJ_G0022285
 protein coding gene Chr16:88484917-88486088 (-)



Homology
more
  • Human Ortholog
    CLDN17, claudin 17
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLDN17, claudin 17
  • Links
    NCBI Gene ID: 26285
    neXtProt AC: NX_P56750
    UniProt: P56750

  • Chr Location
    21q21.3; chr21:30165565-30166805 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit kidney damage and oxidative stress in the kidney, electrolyte imbalance, hypophagia, polydipsia, constipation, and an early delay in growth but reach normal size by 8-18 weeks.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    757
  • Tissues
    50
  • cDNA Data
    5
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 239931 NCBI Gene Model | MGI Sequence Detail 1172 C57BL/6J ±  kb
    transcript NM_181490 RefSeq | MGI Sequence Detail 1172 C57BL/6  
    polypeptide Q8BXA6 UniProt | EBI | MGI Sequence Detail 224 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 5
      Primer pair 2

      Microarray probesets 1
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 10
    • Earliest
      J:80501 Gitton Y, et al., A gene expression map of human chromosome 21 orthologues in the mouse. Nature. 2002 Dec 5;420(6915):586-90
    • Latest
      J:335294 Redhead Y, et al., Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes. Development. 2023 Apr 15;150(8):dev201077
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory