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Xylt1 Gene Detail
Summary
  • Symbol
    Xylt1
  • Name
    xylosyltransferase 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2451073
    NCBI Gene: 233781
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:116980214-117266853 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 62.93 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2312 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2451073
 protein coding gene Chr7:116980214-117272803 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032893
 protein coding gene Chr7:121161308-121461937 (+)
A/J MGP_AJ_G0032876
 protein coding gene Chr7:118105783-118407832 (+)
AKR/J MGP_AKRJ_G0032808
 protein coding gene Chr7:121123577-121419444 (+)
BALB/cJ MGP_BALBcJ_G0032881
 protein coding gene Chr7:117829215-118126060 (+)
C3H/HeJ MGP_C3HHeJ_G0032591
 protein coding gene Chr7:121034002-121339572 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033387
 protein coding gene Chr7:126015889-126329812 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030359
 protein coding gene Chr7:119583305-119872400 (+)
CAST/EiJ MGP_CASTEiJ_G0031919
 protein coding gene Chr7:112738925-113036730 (+)
CBA/J MGP_CBAJ_G0032564
 protein coding gene Chr7:130214884-130536510 (+)
DBA/2J MGP_DBA2J_G0032716
 protein coding gene Chr7:116164409-116457042 (+)
FVB/NJ MGP_FVBNJ_G0032669
 protein coding gene Chr7:115998445-116296524 (+)
LP/J MGP_LPJ_G0032810
 protein coding gene Chr7:122673712-122959678 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032701
 protein coding gene Chr7:131782043-132091556 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033407
 protein coding gene Chr7:120098597-120392907 (+)
PWK/PhJ MGP_PWKPhJ_G0031627
 protein coding gene Chr7:109034403-109350018 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031474
 protein coding gene Chr7:106847664-107174164 (+)
WSB/EiJ MGP_WSBEiJ_G0032032
 protein coding gene Chr7:120975509-121285089 (+)



Homology
more
  • Human Ortholog
    XYLT1, xylosyltransferase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    XYLT1, xylosyltransferase 1
  • Synonyms
    DBQD2, PXYLT1, XT1, XTI, XT-I, xylT-I, XYLTI
  • Links
    NCBI Gene ID: 64131
    neXtProt AC: NX_Q86Y38
    UniProt: Q86Y38

  • Chr Location
    16p12.3; chr16:17101769-17470960 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human XYLT1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 4 alleles in 4 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit partial preweaning lethality, impaired chondrocyte maturation and decreased skeletal length.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    732
  • Tissues
    3
  • cDNA Data
    3
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 233781 NCBI Gene Model | MGI Sequence Detail 286640 C57BL/6J ±  kb
    transcript NM_175645 RefSeq | MGI Sequence Detail 3070 C57BL/6  
    polypeptide Q811B1 UniProt | EBI | MGI Sequence Detail 953 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 4
      cDNA 3
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 6
    • Earliest
      J:66285 Gotting C, et al., Molecular cloning and expression of human UDP-d-Xylose:Proteoglycan core protein beta-d-xylosyltransferase and its first isoform XT-II. J Mol Biol. 2000 Dec 8;304(4):517-28
    • Latest
      J:336752 Taieb M, et al., Xylosyltransferase I mediates the synthesis of proteoglycans with long glycosaminoglycan chains and controls chondrocyte hypertrophy and collagen fibers organization of in the growth plate. Cell Death Dis. 2023 Jun 9;14(6):355
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory