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Tpm4 Gene Detail
Summary
  • Symbol
    Tpm4
  • Name
    tropomyosin 4
  • Synonyms
    2610528G24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2449202
    NCBI Gene: 326618
  • Alliance
    genome feature page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:72889132-72906986 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 34.81 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    433 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2449202
 protein coding gene Chr8:72884018-72906986 (+)
129S1/SvImJ ENSMUSG00200028141
 protein coding gene Chr8:67261114-67279087 (+)
A/J ENSMUSG00195013756
 protein coding gene Chr8:67599081-67617484 (+)
AKR/J ENSMUSG00220022480
 protein coding gene Chr8:67746133-67764006 (+)
BALB/cJ ENSMUSG00180023461
 protein coding gene Chr8:67444812-67462781 (+)
C3H/HeJ ENSMUSG00175020515
 protein coding gene Chr8:67582862-67600834 (+)
C57BL/6NJ ENSMUSG00215031566
 protein coding gene Chr8:67159792-67178186 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031210
 protein coding gene Chr8:64199894-64217909 (+)
CAST/EiJ ENSTCUG00005033358
 protein coding gene Chr8:67202664-67220665 (+)
CBA/J ENSMUSG00210033483
 protein coding gene Chr8:67489716-67507685 (+)
DBA/2J ENSMUSG00185012235
 protein coding gene Chr8:73650138-73668107 (+)
FVB/NJ ENSMUSG00205035027
 protein coding gene Chr8:66739763-66757732 (+)
JF1/MsJ ENSUMUG00000011945
 protein coding gene Chr8:75982043-76000477 (+)
LP/J ENSMUSG00230031793
 protein coding gene Chr8:77302531-77320476 (+)
NOD/ShiLtJ ENSMUSG00190029839
 protein coding gene Chr8:67472024-67490674 (+)
NZO/HlLtJ ENSMUSG00225047275
 protein coding gene Chr8:80661708-80679678 (+)
PWK/PhJ ENSLUMG00010030079
 protein coding gene Chr8:67384746-67403144 (+)
SPRET/EiJ ENSMSPG00010036732
 protein coding gene Chr8:69140873-69158799 (+)
WSB/EiJ ENSIUOG00005022235
 protein coding gene Chr8:68258271-68276289 (+)



Homology
more
  • Human Ortholog
    TPM4, tropomyosin 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TPM4, tropomyosin 4
  • Synonyms
    BDPLT25, HEL-S-108
  • Links
    NCBI Gene ID: 7171
    UniProt: P67936

  • Chr Location
    19p13.12-p13.11; chr19:16067021-16103011 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TPM4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    8
  • Gene trapped
    2
  • Targeted
    2
  • Genomic Mutations
    1 involving Tpm4
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    12 strains or lines available
Mice heterozygous and homozygous for a null and a missense mutation allele exhibit macrothrombocytompenia. Megakaryocytes show a defect in the terminal stages of platelet production and platelets have a mild defect in function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    600
  • Tissues
    3
  • cDNA Data
    209
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 326618 NCBI Gene Model | MGI Sequence Detail 17855 C57BL/6J ±  kb
transcript NM_001001491 RefSeq | MGI Sequence Detail 2099 C57BL/6  
polypeptide Q6IRU2 UniProt | EBI | MGI Sequence Detail 248 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 210
    cDNA 209
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1919452
References
more
  • Summaries
    All 46
    Developmental Gene Expression 1
    Gene Ontology 9
    Phenotypes 13
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory