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Cadm4 Gene Detail
Summary
  • Symbol
    Cadm4
  • Name
    cell adhesion molecule 4
  • Synonyms
    Igsf4c, Necl-4, SynCAM 4, Tsll2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2449088
    NCBI Gene: 260299
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:24181448-24203958 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 11.03 cM, cytoband A3-B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    601 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2449088
 protein coding gene Chr7:24181448-24203964 (+)
129S1/SvImJ ENSMUSG00200039986
 protein coding gene Chr7:14184468-14206981 (+)
A/J ENSMUSG00195048662
 protein coding gene Chr7:16621211-16643729 (+)
AKR/J ENSMUSG00220049873
 protein coding gene Chr7:27746849-27769371 (-)
BALB/cJ ENSMUSG00180053620
 protein coding gene Chr7:14693205-14715726 (+)
C3H/HeJ ENSMUSG00175046405
 protein coding gene Chr7:15743002-15765634 (+)
C57BL/6NJ ENSMUSG00215054390
 protein coding gene Chr7:14097196-14119717 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029336
 protein coding gene Chr7:23756036-23778148 (+)
CAST/EiJ ENSTCUG00005049625
 protein coding gene Chr7:15791314-15813993 (+)
CBA/J ENSMUSG00210051278
 protein coding gene Chr7:14928741-14951375 (+)
DBA/2J ENSMUSG00185051197
 protein coding gene Chr7:18136938-18159425 (+)
FVB/NJ ENSMUSG00205029565
 protein coding gene Chr7:14933677-14956192 (+)
JF1/MsJ ENSUMUG00000045565
 protein coding gene Chr7:22438563-22461203 (+)
LP/J ENSMUSG00230053163
 protein coding gene Chr7:23410834-23433347 (+)
NOD/ShiLtJ ENSMUSG00190045212
 protein coding gene Chr7:14410463-14433094 (+)
NZO/HlLtJ ENSMUSG00225024962
 protein coding gene Chr7:22078764-22101245 (+)
PWK/PhJ ENSLUMG00010050744
 protein coding gene Chr7:14372669-14395323 (+)
SPRET/EiJ ENSMSPG00010050259
 protein coding gene Chr7:14033784-14056316 (+)
WSB/EiJ ENSIUOG00005051448
 protein coding gene Chr7:8870128-8892635 (+)



Homology
more
  • Human Ortholog
    CADM4, cell adhesion molecule 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CADM4, cell adhesion molecule 4
  • Synonyms
    IGSF4C, Necl-4, NECL4, synCAM4, TSLL2
  • Links
    NCBI Gene ID: 199731
    UniProt: Q8NFZ8

  • Chr Location
    19q13.31; chr19:43622366-43641984 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele do not display myelination abnormalities. Mice with ubiquitous conditional deletion of the gene show myelination abnormalities, decreased nerve conduction velocity, hindlimb rigidity, limb grasping, and impaired coordination.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    617
  • Tissues
    10
  • cDNA Data
    26
  • Literature Summary
    7
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 260299 NCBI Gene Model | MGI Sequence Detail 22511 C57BL/6J ±  kb
transcript NM_153112 RefSeq | MGI Sequence Detail 2155 C57BL/6  
polypeptide Q8R464 UniProt | EBI | MGI Sequence Detail 388 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 28
    cDNA 26
    Primer pair 1
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 54
    Developmental Gene Expression 7
    Gene Ontology 9
    Phenotypes 12
  • Earliest
    J:86990 Fukami T, et al., Isolation of the mouse Tsll1 and Tsll2 genes, orthologues of the human TSLC1-like genes 1 and 2 (TSLL1 and TSLL2). Gene. 2003 Dec 24;323:11-8
  • Latest
    J:389864 Murata K, et al., A novel miniTurbo knock-in mouse reveals a protein interaction network of USP46 in the brain. Exp Anim. 2026 Jan 1;75(1):63-72
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory