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Myo3b Gene Detail
Summary
  • Symbol
    Myo3b
  • Name
    myosin IIIB
  • Synonyms
    A430065P19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2448580
    NCBI Gene: 329421
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:69869470-70259542 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 41.05 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    11365 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2448580
 protein coding gene Chr2:69869464-70259542 (+)
129S1/SvImJ ENSMUSG00200036516
 protein coding gene Chr2:66928873-67318994 (+)
A/J ENSMUSG00195021432
 protein coding gene Chr2:67078702-67468675 (+)
AKR/J ENSMUSG00220038252
 protein coding gene Chr2:67043555-67433508 (+)
BALB/cJ ENSMUSG00180037778
 protein coding gene Chr2:67023450-67416858 (+)
C3H/HeJ ENSMUSG00175035625
 protein coding gene Chr2:67142732-67536127 (+)
C57BL/6NJ ENSMUSG00215024870
 protein coding gene Chr2:66965264-67355374 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023632
 protein coding gene Chr2:64574438-64963713 (+)
CAST/EiJ ENSTCUG00005008950
 protein coding gene Chr2:66451555-66830101 (+)
CBA/J ENSMUSG00210034044
 protein coding gene Chr2:67183029-67576410 (+)
DBA/2J ENSMUSG00185038036
 protein coding gene Chr2:67018592-67411986 (+)
FVB/NJ ENSMUSG00205032461
 protein coding gene Chr2:66492482-66879269 (+)
JF1/MsJ ENSUMUG00000004003
 protein coding gene Chr2:66684915-67073612 (+)
LP/J ENSMUSG00230022011
 protein coding gene Chr2:68854987-69215540 (+)
NOD/ShiLtJ ENSMUSG00190033080
 protein coding gene Chr2:67112054-67501964 (+)
NZO/HlLtJ ENSMUSG00225014383
 protein coding gene Chr2:76597224-76957790 (+)
PWK/PhJ ENSLUMG00010029366
 protein coding gene Chr2:66908164-67295804 (+)
SPRET/EiJ ENSMSPG00010032592
 protein coding gene Chr2:68314916-68705869 (+)
WSB/EiJ ENSIUOG00005019353
 protein coding gene Chr2:67160087-67553267 (+)



Homology
more
  • Human Ortholog
    MYO3B, myosin IIIB
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYO3B, myosin IIIB
  • Links
    NCBI Gene ID: 140469
    UniProt: Q8WXR4

  • Chr Location
    2q31.1; chr2:170178145-170655171 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show a subtle defect in stereocilia staircase step spacing in the extrastriolar regions of the utricle, but have normal hearing thresholds and no overt vestibular dysfunction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    636
  • Tissues
    13
  • cDNA Data
    11
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042064 Ensembl Gene Model | MGI Sequence Detail 390073 C57BL/6J ±  kb
    transcript ENSMUST00000060208 Ensembl | MGI Sequence Detail 6256 Not Applicable  
    polypeptide ENSMUSP00000055362 Ensembl | MGI Sequence Detail 1333 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2443983
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 3
      Gene Ontology 11
      Phenotypes 12
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory