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Ppil2 Gene Detail
Summary
  • Symbol
    Ppil2
  • Name
    peptidylprolyl isomerase (cyclophilin)-like 2
  • Synonyms
    C130078A06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2447857
    NCBI Gene: 66053
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:16904419-16929121 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 10.59 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    651 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2447857
 protein coding gene Chr16:16904419-16929126 (-)
129S1/SvImJ ENSMUSG00200040993
 protein coding gene Chr16:13900950-13925656 (-)
A/J ENSMUSG00195032203
 protein coding gene Chr16:13458172-13482871 (-)
AKR/J ENSMUSG00220039727
 protein coding gene Chr16:13774482-13799184 (-)
BALB/cJ ENSMUSG00180033125
 protein coding gene Chr16:13699458-13724163 (-)
C3H/HeJ ENSMUSG00175046045
 protein coding gene Chr16:13844472-13869172 (-)
C57BL/6NJ ENSMUSG00215030335
 protein coding gene Chr16:13565590-13590292 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020503
 protein coding gene Chr16:13584323-13609043 (-)
CAST/EiJ ENSTCUG00005043748
 protein coding gene Chr16:13760821-13785716 (-)
CBA/J ENSMUSG00210036517
 protein coding gene Chr16:13860798-13885502 (-)
DBA/2J ENSMUSG00185028424
 protein coding gene Chr16:13806954-13831656 (-)
FVB/NJ ENSMUSG00205033063
 protein coding gene Chr16:13814526-13839230 (-)
JF1/MsJ ENSUMUG00000047518
 protein coding gene Chr16:13891659-13915431 (-)
LP/J ENSMUSG00230042358
 protein coding gene Chr16:16384870-16409572 (-)
NOD/ShiLtJ ENSMUSG00190027349
 protein coding gene Chr16:13946888-13971583 (-)
NZO/HlLtJ ENSMUSG00225031732
 protein coding gene Chr16:19630676-19655378 (-)
PWK/PhJ ENSLUMG00010038517
 protein coding gene Chr16:13774560-13798333 (-)
SPRET/EiJ ENSMSPG00010040942
 protein coding gene Chr16:13800483-13825919 (-)
WSB/EiJ ENSIUOG00005040951
 protein coding gene Chr16:13939656-13964366 (-)



Homology
more
  • Human Ortholog
    PPIL2, peptidylprolyl isomerase like 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPIL2, peptidylprolyl isomerase like 2
  • Synonyms
    CYC4, Cyp-60, CYP60, hCyP-60, UBOX7
  • Links
    NCBI Gene ID: 23759
    UniProt: Q13356

  • Chr Location
    22q11.21-q11.22; chr22:21666000-21700015 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    12
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022771 Ensembl Gene Model | MGI Sequence Detail 24703 C57BL/6J ±  kb
transcript ENSMUST00000023455 Ensembl | MGI Sequence Detail 2333 Not Applicable  
polypeptide ENSMUSP00000023455 Ensembl | MGI Sequence Detail 521 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000013084 RING-type E3 ubiquitin-protein ligase PPIL2
    (term hierarchy)
  • EC
    2.3.2.27
  • InterPro Domains
    IPR029000 Cyclophilin-like domain superfamily
    IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
    IPR044666 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like
    IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
    IPR016818 Nitric oxide synthase-interacting protein
    IPR026951 Peptidyl-prolyl cis-trans isomerase like 2, U-box domain
    IPR003613 U-box domain
    IPR013083 Zinc finger, RING/FYVE/PHD-type
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 5
Other
Accession IDs
less
MGI:2146356
References
more
  • Summaries
    All 33
    Gene Ontology 9
    Phenotypes 4
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory