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Tenm4 Gene Detail
Summary
  • Symbol
    Tenm4
  • Name
    teneurin transmembrane protein 4
  • Synonyms
    Doc4, ELM2, l(7)-3Rn, l7Rn3, mKIAA1302, Odz4, Ten-m4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2447063
    NCBI Gene: 23966
  • Alliance
  • Transcription Start Sites
    31 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:95820453-96560300 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 7, 52.53 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7246 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2447063
protein coding gene Chr7:95550262-96560300 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032517
protein coding gene Chr7:98840716-99603367 (+)
A/J MGP_AJ_G0032491
protein coding gene Chr7:96392520-97132173 (+)
AKR/J MGP_AKRJ_G0032427
protein coding gene Chr7:98667453-99429336 (+)
BALB/cJ MGP_BALBcJ_G0032502
protein coding gene Chr7:96080788-96823016 (+)
C3H/HeJ MGP_C3HHeJ_G0032217
protein coding gene Chr7:99050105-99806569 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033000
protein coding gene Chr7:102692196-103463730 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029995
protein coding gene Chr7:98885862-99615742 (+)
CAST/EiJ MGP_CASTEiJ_G0031544
protein coding gene Chr7:90554283-91316008 (+)
CBA/J MGP_CBAJ_G0032184
protein coding gene Chr7:106171015-106964376 (+)
DBA/2J MGP_DBA2J_G0032336
protein coding gene Chr7:94765554-95502330 (+)
FVB/NJ MGP_FVBNJ_G0032292
protein coding gene Chr7:94542954-95285001 (+)
LP/J MGP_LPJ_G0032425
protein coding gene Chr7:100141495-100917828 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032325
protein coding gene Chr7:107769314-108533544 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033022
protein coding gene Chr7:98004608-98750348 (+)
PWK/PhJ MGP_PWKPhJ_G0031262
protein coding gene Chr7:87813086-88558586 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031105
protein coding gene Chr7:85243265-85991808 (+)
WSB/EiJ MGP_WSBEiJ_G0031661
protein coding gene Chr7:98632819-99386883 (+)



Homology
more
  • Human Ortholog
    TENM4, teneurin transmembrane protein 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TENM4, teneurin transmembrane protein 4
  • Synonyms
    Doc4, ETM5, ODZ4, ten-4, TEN4, Ten-M4, TNM4
  • Links
    NCBI Gene ID: 26011
    neXtProt AC: NX_Q6N022
    UniProt: Q6N022

  • Chr Location
    11q14.1; chr11:78652829-79441030 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human TENM4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 7 alleles in 7 genetic backgrounds
    18 phenotypes from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Various ENU-induced alleles cause prenatal lethality associated with impaired mesoderm development and lead to pleiotropic phenotypes. The most severe alleles cause failure of gastrulation and somitogenesis while the least severe one allows survival to adulthood with runting of variable penetrance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048078 Ensembl Gene Model | MGI Sequence Detail 739848 C57BL/6J ±  kb
    transcript ENSMUST00000107165 Ensembl | MGI Sequence Detail 10930 Not Applicable  
    polypeptide ENSMUSP00000102783 Ensembl | MGI Sequence Detail 2833 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 18
      Primer pair 1
      Other 3

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-11691, MGD-MRK-11723, MGI:2142385, MGI:96735
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 13
      Gene Ontology 9
      Phenotypes 44
    • Earliest
      J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
    • Latest
      J:292702 Hayashi C, et al., The extracellular domain of teneurin-4 promotes cell adhesion for oligodendrocyte differentiation. Biochem Biophys Res Commun. 2020 Feb 26;523(1):171-176

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory