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St18 Gene Detail
Summary
  • Symbol
    St18
  • Name
    suppression of tumorigenicity 18
  • Synonyms
    mKIAA0535, Myt3, Nzf3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446700
    NCBI Gene: 240690
  • Alliance
  • Transcription Start Sites
    42 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:6557455-6931164 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 1.89 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    10238 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2446700
protein coding gene Chr1:6557455-6931164 (+)
129S1/SvImJ ENSMUSG00200002088
protein coding gene Chr1:4229357-4321480 (+)
A/J ENSMUSG00195002712
protein coding gene Chr1:4048996-4141066 (+)
AKR/J ENSMUSG00220003521
protein coding gene Chr1:4107108-4199231 (+)
BALB/cJ ENSMUSG00180008443
protein coding gene Chr1:4126319-4218385 (+)
C3H/HeJ ENSMUSG00175000073
protein coding gene Chr1:3990512-4084622 (+)
C57BL/6NJ ENSMUSG00215004128
protein coding gene Chr1:4029876-4121916 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0013932
protein coding gene Chr1:3118577-3457293 (+)
CAST/EiJ ENSTCUG00005002067
protein coding gene Chr1:4382597-4482490 (+)
CBA/J ENSMUSG00210001623
protein coding gene Chr1:3905534-3999647 (+)
DBA/2J ENSMUSG00185004476
protein coding gene Chr1:4921615-5013715 (+)
FVB/NJ ENSMUSG00205005158
protein coding gene Chr1:4191415-4283474 (+)
JF1/MsJ ENSUMUG00000003568
protein coding gene Chr1:4178016-4270446 (+)
LP/J ENSMUSG00230002040
protein coding gene Chr1:4936444-5028565 (+)
NOD/ShiLtJ ENSMUSG00190000996
protein coding gene Chr1:4053816-4145860 (+)
NZO/HlLtJ ENSMUSG00225000099
protein coding gene Chr1:8323607-8415660 (+)
PWK/PhJ ENSLUMG00010002244
protein coding gene Chr1:3755862-3848267 (+)
SPRET/EiJ ENSMSPG00010012797
protein coding gene Chr1:4365624-4498775 (+)
WSB/EiJ ENSIUOG00005010283
protein coding gene Chr1:4013090-4105062 (+)



Homology
more
  • Human Ortholog
    ST18, ST18 C2H2C-type zinc finger transcription factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ST18, ST18 C2H2C-type zinc finger transcription factor
  • Synonyms
    NZF-3, NZF3, ZC2H2C3, ZC2HC10, ZNF387
  • Links
    NCBI Gene ID: 9705
    UniProt: O60284

  • Chr Location
    8q11.23; chr8:52110838-52460983 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Myeloid-specific homozygous knockout causes hyperinflammation and results in increased susceptibility to polymicrobial sepsis, LPS-induced shock and DSS-induced colitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 240690 NCBI Gene Model | MGI Sequence Detail 373710 C57BL/6J ±  kb
    transcript NM_001244692 RefSeq | MGI Sequence Detail 5913 C57BL/6  
    polypeptide Q80TY4 UniProt | EBI | MGI Sequence Detail 1045 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 25
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2138535
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 19
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:83413 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Feb 28;10(1):35-48
    • Latest
      J:370197 Brown ME, et al., Pancreatic islet beta-cell subtypes are derived from biochemically-distinct and nutritionally-regulated islet progenitors. Nat Commun. 2025 Jul 1;16(1):5758

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    09/08/2026
    MGI 6.24
    The Jackson Laboratory