Zfc3h1 MGI Mouse Gene Detail - MGI:2446143 - zinc finger, C3H1-type containing

Symbol

Zfc3h1
Name

zinc finger, C3H1-type containing
Synonyms

Ccdc131, Psrc2

Feature Type

protein coding gene
IDs

MGI:2446143
NCBI Gene: 216345
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr10:115220864-115268677 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 63.51 cM
Mapping Data

1 experiment

SNPs within 2kb

392 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2446143	protein coding gene	Chr10:115220691-115268677 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017738	protein coding gene	Chr10:118089536-118141710 (+)
A/J	MGP_AJ_G0017714	protein coding gene	Chr10:113557573-113606774 (+)
AKR/J	MGP_AKRJ_G0017676	protein coding gene	Chr10:116852986-116901736 (+)
BALB/cJ	MGP_BALBcJ_G0017677	protein coding gene	Chr10:113955575-114003384 (+)
C3H/HeJ	MGP_C3HHeJ_G0017502	protein coding gene	Chr10:117078043-117127658 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018134	protein coding gene	Chr10:122196210-122250685 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015814	protein coding gene	Chr10:108184860-108232175 (+)
CAST/EiJ	MGP_CASTEiJ_G0017064	protein coding gene	Chr10:117310313-117365051 (+)
CBA/J	MGP_CBAJ_G0017471	protein coding gene	Chr10:126961703-127015241 (+)
DBA/2J	MGP_DBA2J_G0017576	protein coding gene	Chr10:112710365-112759139 (+)
FVB/NJ	MGP_FVBNJ_G0017571	protein coding gene	Chr10:111657883-111706096 (+)
LP/J	MGP_LPJ_G0017651	protein coding gene	Chr10:118676392-118728040 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017600	protein coding gene	Chr10:129907172-129957775 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018172	protein coding gene	Chr10:116888096-116939626 (+)
PWK/PhJ	MGP_PWKPhJ_G0016846	protein coding gene	Chr10:112778990-112828022 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016636	protein coding gene	Chr10:115693146-115757817 (+)
WSB/EiJ	MGP_WSBEiJ_G0017124	protein coding gene	Chr10:117065407-117114274 (+)

Human Ortholog

ZFC3H1, zinc finger C3H1-type containing

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZFC3H1, zinc finger C3H1-type containing
Synonyms

CCDC131, CSRC2, PSRC2
Links

HGNC:28328

NCBI Gene ID: 196441

neXtProt AC: NX_O60293

UniProt: O60293
Chr Location

12q21.1; chr12:71609599-71667725 (-) GRCh38

MGI Vertebrate Homology

Zfc3h1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ZFC3H1
Gene Tree

Zfc3h1

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

3
Targeted

2
Genomic Mutations

1 involving Zfc3h1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

69 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

4
GO References

2

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

91

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase zfc3h1

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All Sequences

53
RefSeq

14
UniProt

5
CCDS

CCDS36062.1

Ensembl

ENSMUSG00000034163 (Evidence)
NCBI Gene

216345

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034163	Ensembl Gene Model \| MGI Sequence Detail	47814	C57BL/6J	± kb
transcript	ENSMUST00000036044	Ensembl \| MGI Sequence Detail	6957	Not Applicable
polypeptide	ENSMUSP00000044069	Ensembl \| MGI Sequence Detail	1992	Not Applicable

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UniProt

5 Sequences
InterPro Domains

IPR003107 HAT (Half-A-TPR) repeat

IPR039278 NURS complex subunit red1

IPR019607 Putative zinc-finger domain

IPR011990 Tetratricopeptide-like helical domain superfamily

IPR019734 Tetratricopeptide repeat

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All nucleic 91

cDNA 91

Microarray probesets 2

Summaries

All 32

Gene Ontology 2

Phenotypes 12
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

TSS for Zfc3h1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr95813	Chr10:115219822-115219855 (+)	-1,025 bp
Tssr95814	Chr10:115220826-115220854 (+)	-24 bp
Tssr95815	Chr10:115220856-115220926 (+)	27 bp
Tssr95816	Chr10:115220950-115220962 (+)	92 bp
Tssr95817	Chr10:115224834-115224842 (+)	3,974 bp
Tssr95819	Chr10:115237166-115237173 (+)	16,306 bp
Tssr95820	Chr10:115244767-115244779 (+)	23,909 bp
Tssr95821	Chr10:115247291-115247297 (+)	26,430 bp
Tssr95822	Chr10:115258238-115258243 (+)	37,377 bp
Tssr95823	Chr10:115263224-115263237 (+)	42,367 bp
Tssr95824	Chr10:115266786-115266810 (+)	45,934 bp
Tssr95825	Chr10:115266811-115266826 (+)	45,955 bp
Tssr95826	Chr10:115266842-115266851 (+)	45,983 bp
Tssr95827	Chr10:115266974-115266986 (+)	46,116 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23