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Thtpa Gene Detail
Summary
  • Symbol
    Thtpa
  • Name
    thiamine triphosphatase
  • Synonyms
    MGC:38198, ThTPase
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446078
    NCBI Gene: 105663
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:55332241-55336443 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 28.07 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    41 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2446078
 protein coding gene Chr14:55332241-55336452 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021338
 protein coding gene Chr14:49054801-49099913 (+)
A/J MGP_AJ_G0021297
 protein coding gene Chr14:48074352-48119413 (+)
AKR/J MGP_AKRJ_G0021273
 protein coding gene Chr14:49823961-49868991 (+)
BALB/cJ MGP_BALBcJ_G0021301
 protein coding gene Chr14:48051969-48097031 (+)
C3H/HeJ MGP_C3HHeJ_G0021081
 protein coding gene Chr14:49512507-49559113 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021739
 protein coding gene Chr14:51542935-51588548 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019286
 protein coding gene Chr14:46479375-46524658 (+)
CAST/EiJ MGP_CASTEiJ_G0020600
 protein coding gene Chr14:45759814-45808190 (+)
CBA/J MGP_CBAJ_G0021048
 protein coding gene Chr14:53098410-53143500 (+)
DBA/2J MGP_DBA2J_G0021169
 protein coding gene Chr14:47814332-47859407 (+)
FVB/NJ MGP_FVBNJ_G0021151
 protein coding gene Chr14:47281095-47326923 (+)
LP/J MGP_LPJ_G0021243
 protein coding gene Chr14:50104596-50150440 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021175
 protein coding gene Chr14:52463746-52508814 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021766
 protein coding gene Chr14:49008626-49054462 (+)
PWK/PhJ MGP_PWKPhJ_G0020347
 protein coding gene Chr14:44354172-44399602 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020175
 protein coding gene Chr14:44991178-45045309 (+)
WSB/EiJ MGP_WSBEiJ_G0020653
 protein coding gene Chr14:49303683-49350197 (+)



Homology
more
  • Human Ortholog
    THTPA, thiamine triphosphatase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    THTPA, thiamine triphosphatase
  • Synonyms
    THTP, THTPASE
  • Links
    NCBI Gene ID: 79178
    neXtProt AC: NX_Q9BU02
    UniProt: Q9BU02

  • Chr Location
    14q11.2; chr14:23511760-23560271 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Targeted
    1
  • Genomic Mutations
    1 involving Thtpa
  • Find Mice (IMSR)
    11 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    824
  • Tissues
    99
  • cDNA Data
    7
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045691 Ensembl Gene Model | MGI Sequence Detail 4203 C57BL/6J ±  kb
transcript ENSMUST00000050575 Ensembl | MGI Sequence Detail 2830 Not Applicable  
polypeptide ENSMUSP00000056026 Ensembl | MGI Sequence Detail 224 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 2
Other
Accession IDs
less
MGI:2145802
References
more
  • Summaries
    All 32
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory