Phlpp2 MGI Mouse Gene Detail - MGI:2444928 - PH domain and leucine rich repeat protein phosphatase 2

Symbol

Phlpp2
Name

PH domain and leucine rich repeat protein phosphatase 2
Synonyms

C130044A18Rik, Phlppl

Feature Type

protein coding gene
IDs

MGI:2444928
NCBI Gene: 244650
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr8:110595174-110671303 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 57.33 cM
Mapping Data

2 experiments

SNPs within 2kb

223 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444928	protein coding gene	Chr8:110595149-110671303 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034115	protein coding gene	Chr8:112484645-112560336 (+)
A/J	MGP_AJ_G0034094	protein coding gene	Chr8:107927318-107999628 (+)
AKR/J	MGP_AKRJ_G0034021	protein coding gene	Chr8:111089097-111166112 (+)
BALB/cJ	MGP_BALBcJ_G0034088	protein coding gene	Chr8:108133046-108206589 (+)
C3H/HeJ	MGP_C3HHeJ_G0033799	protein coding gene	Chr8:111798679-111871712 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034608	protein coding gene	Chr8:116453603-116529652 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031550	protein coding gene	Chr8:100955838-101033850 (+)
CAST/EiJ	MGP_CASTEiJ_G0033126	protein coding gene	Chr8:111399554-111483688 (+)
CBA/J	MGP_CBAJ_G0033773	protein coding gene	Chr8:120366866-120449226 (+)
DBA/2J	MGP_DBA2J_G0033928	protein coding gene	Chr8:107251923-107324655 (+)
FVB/NJ	MGP_FVBNJ_G0033872	protein coding gene	Chr8:106201616-106273153 (+)
LP/J	MGP_LPJ_G0034018	protein coding gene	Chr8:112661613-112738409 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033918	protein coding gene	Chr8:123382951-123469044 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034627	protein coding gene	Chr8:111050168-111127052 (+)
PWK/PhJ	MGP_PWKPhJ_G0032829	protein coding gene	Chr8:106808384-106888908 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032668	protein coding gene	Chr8:109732729-109812529 (+)
WSB/EiJ	MGP_WSBEiJ_G0033242	protein coding gene	Chr8:111735391-111816102 (+)

Human Ortholog

PHLPP2, PH domain and leucine rich repeat protein phosphatase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PHLPP2, PH domain and leucine rich repeat protein phosphatase 2
Synonyms

PHLPPL, PPM3B
Links

HGNC:29149

NCBI Gene ID: 23035

neXtProt AC: NX_Q6ZVD8

UniProt: Q6ZVD8
Chr Location

16q22.2; chr16:71637835-71724701 (-) GRCh38

MGI Vertebrate Homology

Phlpp2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PHLPP2
Gene Tree

Phlpp2

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
2 phenotypes from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

4
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

60 strains or lines available

Mice homozygous for a knock-out allele exhibit normal susceptibility to DSS-induced colitis.

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All GO Annotations

15
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

713
Tissues

5
cDNA Data

30
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase phlpp2

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All Sequences

48
RefSeq

8
UniProt

3
CCDS

CCDS57644.1

Ensembl

ENSMUSG00000031732 (Evidence)
NCBI Gene

244650

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031732	Ensembl Gene Model \| MGI Sequence Detail	76130	C57BL/6J	± kb
transcript	ENSMUST00000179721	Ensembl \| MGI Sequence Detail	7846	Not Applicable
polypeptide	ENSMUSP00000136166	Ensembl \| MGI Sequence Detail	1355	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000012668 PH domain leucine-rich repeat-containing protein phosphatase 2

(term hierarchy)
EC

3.1.3.16
InterPro Domains

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype

IPR001932 PPM-type phosphatase-like domain

IPR036457 PPM-type phosphatase-like domain superfamily

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All nucleic 31

cDNA 31

Microarray probesets 4

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MGI:2142574

Summaries

All 44

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 12
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:324786 Lupse B, et al., Inhibition of PHLPP1/2 phosphatases rescues pancreatic beta-cells in diabetes. Cell Rep. 2021 Aug 3;36(5):109490

TSS for Phlpp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr79378	Chr8:110595163-110595216 (+)	16 bp
Tssr79379	Chr8:110595218-110595241 (+)	56 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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