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Abra Gene Detail
Summary
  • Symbol
    Abra
  • Name
    actin-binding Rho activating protein
  • Synonyms
    C130068O12Rik, STARS
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444891
    NCBI Gene: 223513
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:41728689-41733116 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 16.42 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    218 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444891
 protein coding gene Chr15:41727472-41733116 (-)
129S1/SvImJ ENSMUSG00200025168
 protein coding gene Chr15:38691919-38697549 (-)
A/J ENSMUSG00195033499
 protein coding gene Chr15:38673937-38679574 (-)
AKR/J ENSMUSG00220026068
 protein coding gene Chr15:38568391-38574020 (-)
BALB/cJ ENSMUSG00180030568
 protein coding gene Chr15:38646994-38652640 (-)
C3H/HeJ ENSMUSG00175025356
 protein coding gene Chr15:38822907-38828536 (-)
C57BL/6NJ ENSMUSG00215016403
 protein coding gene Chr15:38641513-38647159 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019765
 protein coding gene Chr15:36518891-36523247 (-)
CAST/EiJ ENSTCUG00005010194
 protein coding gene Chr15:38648620-38656357 (-)
CBA/J ENSMUSG00210017965
 protein coding gene Chr15:38767422-38773054 (-)
DBA/2J ENSMUSG00185033406
 protein coding gene Chr15:38748292-38753924 (-)
FVB/NJ ENSMUSG00205026100
 protein coding gene Chr15:38631580-38637212 (-)
JF1/MsJ ENSUMUG00000032524
 protein coding gene Chr15:38598332-38603952 (-)
LP/J ENSMUSG00230014218
 protein coding gene Chr15:42074487-42080117 (-)
NOD/ShiLtJ ENSMUSG00190029225
 protein coding gene Chr15:38702073-38707704 (-)
NZO/HlLtJ ENSMUSG00225037565
 protein coding gene Chr15:42426512-42432144 (-)
PWK/PhJ ENSLUMG00010030768
 protein coding gene Chr15:38768266-38773886 (-)
SPRET/EiJ ENSMSPG00010012611
 protein coding gene Chr15:39593656-39597799 (-)
WSB/EiJ ENSIUOG00005030236
 protein coding gene Chr15:38730518-38736152 (-)



Homology
more
  • Human Ortholog
    ABRA, actin binding Rho activating protein
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ABRA, actin binding Rho activating protein
  • Synonyms
    STARS
  • Links
    NCBI Gene ID: 137735
    UniProt: Q8N0Z2

  • Chr Location
    8q23.1; chr8:106759483-106770244 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    1
  • Spontaneous
    1
  • Targeted
    1
  • Genomic Mutations
    3 involving Abra
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    16 strains or lines available
Mice homozygous for a knock-out allele exhibit impaired arteriogenesis following occlusion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    658
  • Tissues
    33
  • cDNA Data
    15
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 223513 NCBI Gene Model | MGI Sequence Detail 4428 C57BL/6J ±  kb
transcript NM_175456 RefSeq | MGI Sequence Detail 1762 C57BL/6  
polypeptide Q8BUZ1 UniProt | EBI | MGI Sequence Detail 375 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 15
    Primer pair 2
    Antibodies 2

    Microarray probesets 3
References
more
  • Summaries
    All 46
    Developmental Gene Expression 7
    Gene Ontology 10
    Phenotypes 10
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:278242 Xia M, et al., HAND2-mediated epithelial maintenance and integrity in cardiac outflow tract morphogenesis. Development. 2019 Jul 4;146(13):dev177477
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory