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Atad2b Gene Detail
Summary
  • Symbol
    Atad2b
  • Name
    ATPase family, AAA domain containing 2B
  • Synonyms
    1110014E10Rik, D530031C13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444798
    NCBI Gene: 320817
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:4967353-5097394 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 2.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2926 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444798
 protein coding gene Chr12:4964404-5097396 (+)
129S1/SvImJ ENSMUSG00200022486
 protein coding gene Chr12:1928287-2058533 (+)
A/J ENSMUSG00195015043
 protein coding gene Chr12:1956058-2086486 (+)
AKR/J ENSMUSG00220027841
 protein coding gene Chr12:1953581-2084016 (+)
BALB/cJ ENSMUSG00180014708
 protein coding gene Chr12:1952522-2082951 (+)
C3H/HeJ ENSMUSG00175009511
 protein coding gene Chr12:1931844-2062350 (+)
C57BL/6NJ ENSMUSG00215018402
 protein coding gene Chr12:1883117-2013536 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017595
 protein coding gene Chr12:1782413-1911460 (+)
CAST/EiJ ENSTCUG00005020955
 protein coding gene Chr12:1762362-1892559 (+)
CBA/J ENSMUSG00210013199
 protein coding gene Chr12:1951585-2082071 (+)
DBA/2J ENSMUSG00185020800
 protein coding gene Chr12:1935255-2065678 (+)
FVB/NJ ENSMUSG00205003021
 protein coding gene Chr12:1732966-1863398 (+)
JF1/MsJ ENSUMUG00000015364
 protein coding gene Chr12:1928270-2058663 (+)
LP/J ENSMUSG00230011278
 protein coding gene Chr12:3763315-3893737 (+)
NOD/ShiLtJ ENSMUSG00190007885
 protein coding gene Chr12:3174566-3305254 (+)
NZO/HlLtJ ENSMUSG00225017865
 protein coding gene Chr12:5823396-5953823 (+)
PWK/PhJ ENSLUMG00010016258
 protein coding gene Chr12:1755014-1885204 (+)
SPRET/EiJ ENSMSPG00010004784
 protein coding gene Chr12:2162240-2294443 (+)
WSB/EiJ ENSIUOG00005002176
 protein coding gene Chr12:1937642-2068797 (+)



Homology
more
  • Human Ortholog
    ATAD2B, ATPase family AAA domain containing 2B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATAD2B, ATPase family AAA domain containing 2B
  • Links
    NCBI Gene ID: 54454
    UniProt: Q9ULI0

  • Chr Location
    2p24.1-p23.3; chr2:23677969-23927164 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruption exhibit reduced body size and fertility in female mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    75
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052812 Ensembl Gene Model | MGI Sequence Detail 130042 C57BL/6J ±  kb
    transcript ENSMUST00000045664 Ensembl | MGI Sequence Detail 8035 Not Applicable  
    polypeptide ENSMUSP00000047445 Ensembl | MGI Sequence Detail 1460 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR041569 AAA ATPase, AAA+ lid domain
      IPR003593 AAA+ ATPase domain
      IPR061960 ATAD2 ATPase, C-terminal domain
      IPR003960 ATPase, AAA-type, conserved site
      IPR003959 ATPase, AAA-type, core
      IPR045199 ATPase family AAA domain-containing protein ATAD2-like
      IPR001487 Bromodomain
      IPR018359 Bromodomain, conserved site
      IPR036427 Bromodomain-like superfamily
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      E9Q166 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 77
      Genomic 2
      cDNA 75

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1915840, MGI:2145096, MGI:3040673
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory