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Mysm1 Gene Detail
Summary
  • Symbol
    Mysm1
  • Name
    myb-like, SWIRM and MPN domains 1
  • Synonyms
    C130067A03Rik, C530050H10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444584
    NCBI Gene: 320713
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:94830277-94867337 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 43.34 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1042 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444584
 protein coding gene Chr4:94830274-94867392 (-)
129S1/SvImJ ENSMUSG00200009185
 protein coding gene Chr4:89786782-89823908 (-)
A/J ENSMUSG00195008766
 protein coding gene Chr4:90334077-90371203 (-)
AKR/J ENSMUSG00220019420
 protein coding gene Chr4:89746361-89783489 (-)
BALB/cJ ENSMUSG00180005860
 protein coding gene Chr4:89281391-89318514 (-)
C3H/HeJ ENSMUSG00175007500
 protein coding gene Chr4:90220649-90257768 (-)
C57BL/6NJ ENSMUSG00215015896
 protein coding gene Chr4:90199388-90236449 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026169
 protein coding gene Chr4:87166803-87203621 (-)
CAST/EiJ ENSTCUG00005018363
 protein coding gene Chr4:89595859-89633714 (-)
CBA/J ENSMUSG00210016087
 protein coding gene Chr4:89797223-89834350 (-)
DBA/2J ENSMUSG00185002816
 protein coding gene Chr4:90599674-90636492 (-)
FVB/NJ ENSMUSG00205012948
 protein coding gene Chr4:88752950-88790002 (-)
JF1/MsJ ENSUMUG00000002560
 protein coding gene Chr4:90714348-90751999 (-)
LP/J ENSMUSG00230017567
 protein coding gene Chr4:93895813-93932942 (-)
NOD/ShiLtJ ENSMUSG00190017085
 protein coding gene Chr4:89241495-89278626 (-)
NZO/HlLtJ ENSMUSG00225002852
 protein coding gene Chr4:99051277-99088333 (-)
PWK/PhJ ENSLUMG00010003195
 protein coding gene Chr4:88457601-88495147 (-)
SPRET/EiJ ENSMSPG00010015052
 protein coding gene Chr4:90511639-90545928 (-)
WSB/EiJ ENSIUOG00005012475
 protein coding gene Chr4:89573525-89610581 (-)



Homology
more
  • Human Ortholog
    MYSM1, Myb like, SWIRM and MPN domains 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYSM1, Myb like, SWIRM and MPN domains 1
  • Synonyms
    2A-DUB, 2ADUB, BMFS4
  • Links
    NCBI Gene ID: 114803
    UniProt: Q5VVJ2

  • Chr Location
    1p32.1; chr1:58643440-58700090 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MYSM1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 2 alleles in 3 genetic backgrounds
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes exhibit pigmentation, epidermis, hair follicle and hair cycle abnormalities. Abnormalities in behavior, the hematopoietic and immune systems, body size, metabolism, and skeletal and eye phenotypes are also seen.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    601
  • Tissues
    2
  • cDNA Data
    12
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000062627 Ensembl Gene Model | MGI Sequence Detail 37061 C57BL/6J ±  kb
    transcript ENSMUST00000075872 Ensembl | MGI Sequence Detail 7420 Not Applicable  
    polypeptide ENSMUSP00000075269 Ensembl | MGI Sequence Detail 819 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 12
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2442057
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 38
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:370839 Mousa M, et al., Chromatin-binding deubiquitinase MYSM1 acts in haematopoietic progenitors to control dendritic cell development and to program dendritic cell responses to microbial stimulation. Immunology. 2024 May;172(1):109-126
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory