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Tmem63c Gene Detail
Summary
  • Symbol
    Tmem63c
  • Name
    transmembrane protein 63c
  • Synonyms
    9330187M14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444386
    NCBI Gene: 217733
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:87068114-87136817 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 41.21 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    256 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444386
 protein coding gene Chr12:87068114-87138598 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019976
 protein coding gene Chr12:87902752-87981793 (+)
A/J MGP_AJ_G0019934
 protein coding gene Chr12:84564939-84637403 (+)
AKR/J MGP_AKRJ_G0019909
 protein coding gene Chr12:86855424-86929210 (+)
BALB/cJ MGP_BALBcJ_G0019913
 protein coding gene Chr12:84899767-84969685 (+)
C3H/HeJ MGP_C3HHeJ_G0019719
 protein coding gene Chr12:87345163-87419155 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020365
 protein coding gene Chr12:90440820-90514752 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017983
 protein coding gene Chr12:81450692-81522397 (+)
CAST/EiJ MGP_CASTEiJ_G0019269
 protein coding gene Chr12:82367009-82443250 (+)
CBA/J MGP_CBAJ_G0019691
 protein coding gene Chr12:93922723-93998222 (+)
DBA/2J MGP_DBA2J_G0019804
 protein coding gene Chr12:84054424-84124885 (+)
FVB/NJ MGP_FVBNJ_G0019791
 protein coding gene Chr12:83050550-83121884 (+)
LP/J MGP_LPJ_G0019878
 protein coding gene Chr12:87783332-87859516 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019830
 protein coding gene Chr12:96666990-96740665 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020397
 protein coding gene Chr12:86486839-86558875 (+)
PWK/PhJ MGP_PWKPhJ_G0019033
 protein coding gene Chr12:78611245-78682998 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018828
 protein coding gene Chr12:80980644-81052588 (+)
WSB/EiJ MGP_WSBEiJ_G0019322
 protein coding gene Chr12:87231675-87332756 (+)



Homology
more
  • Human Ortholog
    TMEM63C, transmembrane protein 63C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM63C, transmembrane protein 63C
  • Synonyms
    C14orf171, CSC1, hsCSC1, SPG87
  • Links
    NCBI Gene ID: 57156
    neXtProt AC: NX_Q9P1W3
    UniProt: Q9P1W3

  • Chr Location
    14q24.3; chr14:77116568-77259495 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TMEM63C associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034145 Ensembl Gene Model | MGI Sequence Detail 68704 C57BL/6J ±  kb
    transcript ENSMUST00000146292 Ensembl | MGI Sequence Detail 3455 Not Applicable  
    polypeptide ENSMUSP00000119872 Ensembl | MGI Sequence Detail 802 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000032499 calcium permeable stress-gated cation channel 1
      (term hierarchy)
    • PDB
      8K0B
    • InterPro Domains
      IPR045122 Calcium permeable stress-gated cation channel 1-like
      IPR003864 CSC1/OSCA1-like, 7TM region
      IPR027815 CSC1/OSCA1-like, cytosolic domain
      IPR032880 CSC1/OSCA1-like, N-terminal transmembrane domain
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12

      Microarray probesets 2
    References
    more
    • Summaries
      All 31
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:344717 Qin Y, et al., Cryo-EM structure of TMEM63C suggests it functions as a monomer. Nat Commun. 2023 Nov 9;14(1):7265
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory