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Islr2 Gene Detail
Summary
  • Symbol
    Islr2
  • Name
    immunoglobulin superfamily containing leucine-rich repeat 2
  • Synonyms
    B930052A04Rik, Linx, mbu-3, mKIAA1465
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444277
    NCBI Gene: 320563
  • Alliance
    genome feature page
  • Transcription Start Sites
    31 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:58103580-58111602 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 31.63 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    208 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444277
 protein coding gene Chr9:58103580-58113563 (-)
129S1/SvImJ ENSMUSG00200035507
 protein coding gene Chr9:55230293-55238315 (-)
A/J ENSMUSG00195038946
 protein coding gene Chr9:54937448-54945472 (-)
AKR/J ENSMUSG00220027654
 protein coding gene Chr9:55072378-55080411 (-)
BALB/cJ ENSMUSG00180014996
 protein coding gene Chr9:55045056-55053078 (-)
C3H/HeJ ENSMUSG00175021260
 protein coding gene Chr9:55064192-55072216 (-)
C57BL/6NJ ENSMUSG00215026330
 protein coding gene Chr9:55038391-55046413 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032289
 protein coding gene Chr9:54889360-54897362 (-)
CAST/EiJ ENSTCUG00005019468
 protein coding gene Chr9:54962312-54970340 (-)
CBA/J ENSMUSG00210038327
 protein coding gene Chr9:55166260-55174282 (-)
DBA/2J ENSMUSG00185042156
 protein coding gene Chr9:55189501-55197525 (-)
FVB/NJ ENSMUSG00205022275
 protein coding gene Chr9:55495697-55503730 (-)
JF1/MsJ ENSUMUG00000023129
 protein coding gene Chr9:55205183-55213224 (-)
LP/J ENSMUSG00230038620
 protein coding gene Chr9:55430031-55438053 (-)
NOD/ShiLtJ ENSMUSG00190027225
 protein coding gene Chr9:55256862-55264893 (-)
NZO/HlLtJ ENSMUSG00225027357
 protein coding gene Chr9:55475566-55483588 (-)
PWK/PhJ ENSLUMG00010034862
 protein coding gene Chr9:55163878-55171884 (-)
SPRET/EiJ ENSMSPG00010025578
 protein coding gene Chr9:56206073-56213207 (-)
WSB/EiJ ENSIUOG00005035821
 protein coding gene Chr9:54669933-54677965 (-)



Homology
more
  • Human Ortholog
    ISLR2, immunoglobulin superfamily containing leucine rich repeat 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ISLR2, immunoglobulin superfamily containing leucine rich repeat 2
  • Synonyms
    LINX
  • Links
    NCBI Gene ID: 57611
    UniProt: Q6UXK2

  • Chr Location
    15q24.1; chr15:74100311-74141826 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit perinatal lethality, absent tail pinch response, and defective peroneal and tibial nerve morphology and branch extension.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    864
  • Tissues
    204
  • cDNA Data
    109
  • Literature Summary
    28
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000051243 Ensembl Gene Model | MGI Sequence Detail 8023 C57BL/6J ±  kb
    transcript ENSMUST00000163200 Ensembl | MGI Sequence Detail 4123 Not Applicable  
    polypeptide ENSMUSP00000130879 Ensembl | MGI Sequence Detail 789 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000030678 immunoglobulin superfamily containing leucine-rich repeat protein 2
      (term hierarchy)
    • InterPro Domains
      IPR000483 Cysteine-rich flanking region, C-terminal
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR003591 Leucine-rich repeat, typical subtype
    • GlyGen
      Q5RKR3 9 sites, 10 N-linked glycans (7 sites)
    Molecular
    Reagents
    less
    • All nucleic 126
      cDNA 111
      Primer pair 10
      Other 5
      Antibodies 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 28
      Gene Ontology 4
      Phenotypes 10
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:389152 Ali S, et al., A central role for Islr2 (Linx) in direct pathway striatal projection neurons for the correct formation of the internal capsule and cerebral peduncle. Dev Biol. 2026 Jul 4;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory