About   Help   FAQ
Ythdf2 Gene Detail
Summary
  • Symbol
    Ythdf2
  • Name
    YTH N6-methyladenosine RNA binding protein 2
  • Synonyms
    9430020E02Rik, HGRG8, NY-REN-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444233
    NCBI Gene: 213541
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:131912227-131939567 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 64.92 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    628 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444233
 protein coding gene Chr4:131912223-131939614 (-)
129S1/SvImJ ENSMUSG00200019781
 protein coding gene Chr4:125366720-125394091 (-)
A/J ENSMUSG00195041434
 protein coding gene Chr4:126691322-126718714 (-)
AKR/J ENSMUSG00220039970
 protein coding gene Chr4:125683082-125710472 (-)
BALB/cJ ENSMUSG00180041382
 protein coding gene Chr4:124325064-124352461 (-)
C3H/HeJ ENSMUSG00175043950
 protein coding gene Chr4:125337453-125364851 (-)
C57BL/6NJ ENSMUSG00215049159
 protein coding gene Chr4:126841369-126868770 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026560
 protein coding gene Chr4:121842045-121850148 (-)
CAST/EiJ ENSTCUG00005047751
 protein coding gene Chr4:126233589-126260689 (-)
CBA/J ENSMUSG00210053054
 protein coding gene Chr4:124966422-124993817 (-)
DBA/2J ENSMUSG00185048881
 protein coding gene Chr4:126498856-126526233 (-)
FVB/NJ ENSMUSG00205031427
 protein coding gene Chr4:124740491-124767711 (-)
JF1/MsJ ENSUMUG00000040808
 protein coding gene Chr4:127163983-127191425 (-)
LP/J ENSMUSG00230034207
 protein coding gene Chr4:130305216-130332585 (-)
NOD/ShiLtJ ENSMUSG00190041147
 protein coding gene Chr4:124731157-124758546 (-)
NZO/HlLtJ ENSMUSG00225026198
 protein coding gene Chr4:136209477-136236862 (-)
PWK/PhJ ENSLUMG00010047101
 protein coding gene Chr4:124184300-124211693 (-)
SPRET/EiJ ENSMSPG00010036162
 protein coding gene Chr4:126259602-126285521 (-)
WSB/EiJ ENSIUOG00005035477
 protein coding gene Chr4:124619578-124646979 (-)



Homology
more
  • Human Ortholog
    YTHDF2, YTH N6-methyladenosine RNA binding protein F2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    YTHDF2, YTH N6-methyladenosine RNA binding protein F2
  • Synonyms
    CAHL, DF2, HGRG8, NY-REN-2
  • Links
    NCBI Gene ID: 51441
    UniProt: Q9Y5A9

  • Chr Location
    1p35.3; chr1:28736621-28769784 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 4 alleles in 6 genetic backgrounds
    3 phenotypes from multigenic genotypes
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit female infertility and background-sensitive preweaning lethality. Male homozygotes generated by different targeting strategies show differing reproductive phenotypes ranging from normal male fertility to hypofertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    76
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    607
  • Tissues
    6
  • cDNA Data
    17
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 213541 NCBI Gene Model | MGI Sequence Detail 27341 C57BL/6J ±  kb
    transcript NM_145393 RefSeq | MGI Sequence Detail 4078 C57BL/6  
    polypeptide Q91YT7 UniProt | EBI | MGI Sequence Detail 579 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 17
      Primer pair 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 101
      Developmental Gene Expression 10
      Gene Ontology 13
      Phenotypes 46
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:388020 Pan W, et al., Neuronal YTHDF2 suppresses innate immune activation in Abeta pathology by promoting m(6)A-dependent decay of cytosolic mitochondrial mRNAs. Sci Adv. 2026 Jun 19;12(25):eadz0887
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory