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Ppp1r15b Gene Detail
Summary
  • Symbol
    Ppp1r15b
  • Name
    protein phosphatase 1, regulatory subunit 15B
  • Synonyms
    1810033K10Rik, C530022L24Rik, CReP
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444211
    NCBI Gene: 108954
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:133058904-133067538 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 57.80 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    55 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444211
 protein coding gene Chr1:133058881-133067538 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016480
 protein coding gene Chr1:136653401-136662053 (+)
A/J MGP_AJ_G0016463
 protein coding gene Chr1:131583399-131594673 (+)
AKR/J MGP_AKRJ_G0016428
 protein coding gene Chr1:135462024-135470635 (+)
BALB/cJ MGP_BALBcJ_G0016423
 protein coding gene Chr1:131916532-131925534 (+)
C3H/HeJ MGP_C3HHeJ_G0016249
 protein coding gene Chr1:135600484-135609122 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016884
 protein coding gene Chr1:141722030-141732441 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014595
 protein coding gene Chr1:124737899-124746708 (+)
CAST/EiJ MGP_CASTEiJ_G0015829
 protein coding gene Chr1:134621843-134633199 (+)
CBA/J MGP_CBAJ_G0016221
 protein coding gene Chr1:146555546-146564009 (+)
DBA/2J MGP_DBA2J_G0016328
 protein coding gene Chr1:130546379-130558133 (+)
FVB/NJ MGP_FVBNJ_G0016327
 protein coding gene Chr1:129195426-129204042 (+)
LP/J MGP_LPJ_G0016399
 protein coding gene Chr1:137962319-137973742 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016352
 protein coding gene Chr1:152323090-152332419 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016920
 protein coding gene Chr1:135209811-135218384 (+)
PWK/PhJ MGP_PWKPhJ_G0015615
 protein coding gene Chr1:129554380-129563046 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015402
 protein coding gene Chr1:134163027-134171693 (+)
WSB/EiJ MGP_WSBEiJ_G0015891
 protein coding gene Chr1:135211592-135223558 (+)



Homology
more
  • Human Ortholog
    PPP1R15B, protein phosphatase 1 regulatory subunit 15B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP1R15B, protein phosphatase 1 regulatory subunit 15B
  • Synonyms
    CREP, MSSGM2
  • Links
    NCBI Gene ID: 84919
    UniProt: Q5SWA1

  • Chr Location
    1q32.1; chr1:204395826-204411887 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    3 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die within the first day after birth with decreased weight at birth and red blood cell counts.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    18
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    188
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 108954 NCBI Gene Model | MGI Sequence Detail 8635 C57BL/6J ±  kb
    transcript NM_133819 RefSeq | MGI Sequence Detail 5588 C57BL/6  
    polypeptide Q8BFW3 UniProt | EBI | MGI Sequence Detail 697 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000013117 protein phosphatase 1 regulatory subunit 15B
      (term hierarchy)
    • InterPro Domains
      IPR019523 Protein phosphatase 1, regulatory subunit 15A/B, C-terminal
      IPR019512 Protein phosphatase 1, regulatory subunit 15B, N-terminal
    Molecular
    Reagents
    less
    • All nucleic 189
      cDNA 189

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1920896, MGI:2138301
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:333724 Park EJ, et al., Ssu72 phosphatase is essential for thermogenic adaptation by regulating cytosolic translation. Nat Commun. 2023 Feb 25;14(1):1097
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory