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Nlrc3 Gene Detail
Summary
  • Symbol
    Nlrc3
  • Name
    NLR family, CARD domain containing 3
  • Synonyms
    Caterpiller 16.2, CLR16.2, D230007K08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444070
    NCBI Gene: 268857
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:3762871-3794496 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 2.32 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    171 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444070
 protein coding gene Chr16:3762871-3796881 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022457
 protein coding gene Chr16:395121-428066 (-)
A/J MGP_AJ_G0022418
 protein coding gene Chr16:271212-302110 (-)
AKR/J MGP_AKRJ_G0022395
 protein coding gene Chr16:412722-443424 (-)
BALB/cJ MGP_BALBcJ_G0022423
 protein coding gene Chr16:394173-425057 (-)
C3H/HeJ MGP_C3HHeJ_G0022190
 protein coding gene Chr16:444040-475099 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022872
 protein coding gene Chr16:433769-468863 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020394
 protein coding gene Chr16:224811-252292 (-)
CAST/EiJ MGP_CASTEiJ_G0021717
 protein coding gene Chr16:400753-433305 (-)
CBA/J MGP_CBAJ_G0022159
 protein coding gene Chr16:506570-538463 (-)
DBA/2J MGP_DBA2J_G0022290
 protein coding gene Chr16:377766-409575 (-)
FVB/NJ MGP_FVBNJ_G0022266
 protein coding gene Chr16:346850-377609 (-)
LP/J MGP_LPJ_G0022359
 protein coding gene Chr16:403567-434159 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022288
 protein coding gene Chr16:390730-424192 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022884
 protein coding gene Chr16:375574-407822 (-)
PWK/PhJ MGP_PWKPhJ_G0021457
 protein coding gene Chr16:412020-444772 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021288
 protein coding gene Chr16:477279-517070 (-)
WSB/EiJ MGP_WSBEiJ_G0021766
 protein coding gene Chr16:407748-440951 (-)



Homology
more
  • Human Ortholog
    NLRC3, NLR family CARD domain containing 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NLRC3, NLR family CARD domain containing 3
  • Synonyms
    CLR16.2, NOD3
  • Links
    NCBI Gene ID: 197358
    neXtProt AC: NX_Q7RTR2
    UniProt: Q7RTR2

  • Chr Location
    16p13.3; chr16:3539033-3577403 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit enhanced susceptibility to LPS-induced toxic shock.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    1
  • cDNA Data
    17
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000049871 Ensembl Gene Model | MGI Sequence Detail 31626 C57BL/6J ±  kb
    transcript ENSMUST00000229884 Ensembl | MGI Sequence Detail 3600 Not Applicable  
    polypeptide ENSMUSP00000155241 Ensembl | MGI Sequence Detail 1199 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000011261 NLR family CARD domain-containing protein 3
      (term hierarchy)
    • InterPro Domains
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR041267 NACHT, LRR and PYD domains-containing protein, helical domain HD2
      IPR007111 NACHT nucleoside triphosphatase
      IPR041075 NOD2, winged helix domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 17
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 1
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory