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Atf7 Gene Detail
Summary
  • Symbol
    Atf7
  • Name
    activating transcription factor 7
  • Synonyms
    1110012F10Rik, 9430065F09Rik, C130020M04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443472
    NCBI Gene: 223922
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:102434381-102533899 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 57.66 cM, cytoband F3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1424 from dbSNP Build 142
  • Strain Annotations
    31
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443472
 protein coding gene Chr15:102434381-102533899 (-)
129S1/SvImJ ENSMUSG00200051988
 protein coding gene Chr15:99659315-99727110 (-)
129S1/SvImJ ENSMUSG00200052041
 protein coding gene Chr15:99662007-99662396 (-)
A/J ENSMUSG00195038281
 protein coding gene Chr15:99548831-99616601 (-)
A/J ENSMUSG00195038391
 protein coding gene Chr15:99551502-99551891 (-)
AKR/J ENSMUSG00220048739
 protein coding gene Chr15:99521655-99522044 (-)
AKR/J ENSMUSG00220048700
 protein coding gene Chr15:99518977-99586518 (-)
BALB/cJ ENSMUSG00180038691
 protein coding gene Chr15:99434637-99435026 (-)
BALB/cJ ENSMUSG00180038543
 protein coding gene Chr15:99431949-99499746 (-)
C3H/HeJ ENSMUSG00175045948
 protein coding gene Chr15:99753341-99753730 (-)
C3H/HeJ ENSMUSG00175045792
 protein coding gene Chr15:99750672-99818436 (-)
C57BL/6NJ ENSMUSG00215048669
 protein coding gene Chr15:99475376-99543170 (-)
C57BL/6NJ ENSMUSG00215048757
 protein coding gene Chr15:99478065-99478454 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020359
 protein coding gene Chr15:96367364-96463868 (-)
CAST/EiJ ENSTCUG00005045644
 protein coding gene Chr15:98956372-99023370 (-)
CBA/J ENSMUSG00210027882
 protein coding gene Chr15:99501858-99569627 (-)
CBA/J ENSMUSG00210028004
 protein coding gene Chr15:99504529-99504918 (-)
DBA/2J ENSMUSG00185040700
 protein coding gene Chr15:99518805-99586337 (-)
DBA/2J ENSMUSG00185040843
 protein coding gene Chr15:99521483-99521872 (-)
FVB/NJ ENSMUSG00205041398
 protein coding gene Chr15:99223562-99291100 (-)
FVB/NJ ENSMUSG00205041604
 protein coding gene Chr15:99226242-99226631 (-)
JF1/MsJ ENSUMUG00000048527
 protein coding gene Chr15:98980722-99051432 (-)
LP/J ENSMUSG00230005467
 protein coding gene Chr15:102883016-102883405 (-)
LP/J ENSMUSG00230005460
 protein coding gene Chr15:102880326-102948114 (-)
NOD/ShiLtJ ENSMUSG00190030179
 protein coding gene Chr15:99466346-99466735 (-)
NOD/ShiLtJ ENSMUSG00190029834
 protein coding gene Chr15:99463668-99531196 (-)
NZO/HlLtJ ENSMUSG00225027808
 protein coding gene Chr15:103062643-103063032 (-)
NZO/HlLtJ ENSMUSG00225027782
 protein coding gene Chr15:103059975-103127749 (-)
PWK/PhJ ENSLUMG00010047028
 protein coding gene Chr15:99190897-99262132 (-)
SPRET/EiJ ENSMSPG00010039977
 protein coding gene Chr15:100978528-101073103 (-)
WSB/EiJ ENSIUOG00005030649
 protein coding gene Chr15:99609451-99677283 (-)



Homology
more
  • Human Ortholog
    ATF7, activating transcription factor 7
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATF7, activating transcription factor 7
  • Synonyms
    ATFA
  • Links
    NCBI Gene ID: 11016
    UniProt: P17544

  • Chr Location
    12q13.13; chr12:53507856-53626410 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 3 genetic backgrounds
    12 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one knock-out allele exhibit increased marble burying, increased startle response, and decreased prepulse inhibition.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    669
  • Tissues
    57
  • cDNA Data
    21
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 223922 NCBI Gene Model | MGI Sequence Detail 99519 C57BL/6J ±  kb
    transcript NM_001310066 RefSeq | MGI Sequence Detail 7484 C57BL/6  
    polypeptide Q8R0S1 UniProt | EBI | MGI Sequence Detail 413 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • InterPro Domains
      IPR004827 Basic-leucine zipper domain
      IPR046347 Basic-leucine zipper domain superfamily
      IPR016378 Transcription factor cyclic AMP-dependent, CRE-BP1-type
      IPR036236 Zinc finger C2H2 superfamily
      IPR013087 Zinc finger C2H2-type
    • GlyGen
      Q8R0S1 2 sites, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 22
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1915865, MGI:1924604, MGI:2146037
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 7
      Phenotypes 39
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory