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Unc45b Gene Detail
Summary
  • Symbol
    Unc45b
  • Name
    unc-45 myosin chaperone B
  • Synonyms
    Cmya4, D230041A13Rik, UNC45
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443377
    NCBI Gene: 217012
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:82802112-82834284 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 50.30 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    244 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443377
 protein coding gene Chr11:82801376-82834284 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018835
 protein coding gene Chr11:84199679-84232527 (+)
A/J MGP_AJ_G0018802
 protein coding gene Chr11:80960168-80993860 (+)
AKR/J MGP_AKRJ_G0018772
 protein coding gene Chr11:83391211-83432600 (+)
BALB/cJ MGP_BALBcJ_G0018775
 protein coding gene Chr11:81363736-81399714 (+)
C3H/HeJ MGP_C3HHeJ_G0018589
 protein coding gene Chr11:83421091-83456036 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019227
 protein coding gene Chr11:86717693-86754256 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016861
 protein coding gene Chr11:77923359-77953244 (+)
CAST/EiJ MGP_CASTEiJ_G0018144
 protein coding gene Chr11:84011436-84042037 (+)
CBA/J MGP_CBAJ_G0018560
 protein coding gene Chr11:90471461-90507307 (+)
DBA/2J MGP_DBA2J_G0018668
 protein coding gene Chr11:80534710-80568850 (+)
FVB/NJ MGP_FVBNJ_G0018657
 protein coding gene Chr11:80060092-80092983 (+)
LP/J MGP_LPJ_G0018738
 protein coding gene Chr11:84709366-84745577 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018684
 protein coding gene Chr11:90667868-90703666 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019267
 protein coding gene Chr11:83649920-83681032 (+)
PWK/PhJ MGP_PWKPhJ_G0017914
 protein coding gene Chr11:81356972-81393003 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017705
 protein coding gene Chr11:83272945-83313815 (+)
WSB/EiJ MGP_WSBEiJ_G0018196
 protein coding gene Chr11:83536515-83570085 (+)



Homology
more
  • Human Ortholog
    UNC45B, unc-45 myosin chaperone B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UNC45B, unc-45 myosin chaperone B
  • Synonyms
    CMYA4, CTRCT43, MFM11, SMUNC45, UNC45, UNC-45B
  • Links
    NCBI Gene ID: 146862
    neXtProt AC: NX_Q8IWX7
    UniProt: Q8IWX7

  • Chr Location
    17q12; chr17:35147817-35189345 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human UNC45B associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E9 without placental abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    743
  • Tissues
    12
  • cDNA Data
    10
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 217012 NCBI Gene Model | MGI Sequence Detail 32173 C57BL/6J ±  kb
transcript NM_178680 RefSeq | MGI Sequence Detail 3571 C57BL/6  
polypeptide Q8CGY6 UniProt | EBI | MGI Sequence Detail 931 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 10
    Primer pair 3

    Microarray probesets 2
Other
Accession IDs
less
MGI:2671016
References
more
  • Summaries
    All 46
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 17
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:270838 Wiederstein JL, et al., Skeletal Muscle-Specific Methyltransferase METTL21C Trimethylates p97 and Regulates Autophagy-Associated Protein Breakdown. Cell Rep. 2018 May 1;23(5):1342-1356
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory