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Siglech Gene Detail
Summary
  • Symbol
    Siglech
  • Name
    sialic acid binding Ig-like lectin H
  • Synonyms
    6430529G09Rik, Siglec-H
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443256
    NCBI Gene: 233274
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:55417926-55428673 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 33.42 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    474 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443256
 protein coding gene Chr7:55417916-55429196 (+)
129S1/SvImJ ENSMUSG00200008461
 protein coding gene Chr7:42905145-42914532 (+)
A/J ENSMUSG00195010799
 protein coding gene Chr7:47067130-47076522 (+)
AKR/J ENSMUSG00220010878
 protein coding gene Chr7:41375673-41385066 (+)
BALB/cJ ENSMUSG00180010110
 protein coding gene Chr7:43930795-43940166 (+)
C3H/HeJ ENSMUSG00175003216
 protein coding gene Chr7:44424313-44433704 (+)
C57BL/6NJ ENSMUSG00215001848
 protein coding gene Chr7:43739714-43749102 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029802
 protein coding gene Chr7:58387733-58399062 (+)
CAST/EiJ ENSTCUG00005023159
 protein coding gene Chr7:47294285-47303697 (+)
CBA/J ENSMUSG00210017440
 protein coding gene Chr7:44806022-44815407 (+)
DBA/2J ENSMUSG00185028299
 protein coding gene Chr7:48697298-48706674 (+)
FVB/NJ ENSMUSG00205001343
 protein coding gene Chr7:44504383-44513771 (+)
JF1/MsJ ENSUMUG00000009962
 protein coding gene Chr7:53503849-53513291 (+)
LP/J ENSMUSG00230005538
 protein coding gene Chr7:54244784-54254169 (+)
NOD/ShiLtJ ENSMUSG00190003450
 protein coding gene Chr7:44837095-44846483 (+)
NZO/HlLtJ ENSMUSG00225009936
 protein coding gene Chr7:52423452-52432854 (+)
PWK/PhJ ENSLUMG00010002245
 protein coding gene Chr7:43438382-43449309 (+)
SPRET/EiJ ENSMSPG00010001336
 protein coding gene Chr7:43412035-43421506 (+)
WSB/EiJ ENSIUOG00005005123
 protein coding gene Chr7:45123224-45132607 (+)



Homology
more
  • Human Ortholog
    CD33, CD33 molecule
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD33, CD33 molecule
  • Synonyms
    CD33rSiglec, p67, SIGLEC-3, SIGLEC3
  • Links
    NCBI Gene ID: 945
    UniProt: P20138

  • Chr Location
    19q13.41; chr19:51211076-51243860 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    13 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased T cell proliferation, increased BUN, vacuolated renal tubules, testicular atrophy and poor maturation of seminiferous tubules.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    606
  • Tissues
    6
  • cDNA Data
    9
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000051504 Ensembl Gene Model | MGI Sequence Detail 10748 C57BL/6J ±  kb
    transcript ENSMUST00000165045 Ensembl | MGI Sequence Detail 1062 Not Applicable  
    polypeptide ENSMUSP00000130632 Ensembl | MGI Sequence Detail 332 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • InterPro Domains
      IPR003599 Immunoglobulin domain subtype
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR013106 Immunoglobulin V-set domain
      IPR051036 Sialic acid-binding Ig-like lectin
    • GlyGen
      B7ZMQ6 5 sites, 5 N-linked glycans (5 sites)
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 9
      Primer pair 1
      Antibodies 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 26
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:377065 Tsuji T, et al., Microglia Display Heterogeneous Initial Responses to Disseminated Tumor Cells. Cancer Res. 2025 Dec 10;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory