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Usp40 Gene Detail
Summary
  • Symbol
    Usp40
  • Name
    ubiquitin specific peptidase 40
  • Synonyms
    B230215L03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443184
    NCBI Gene: 227334
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:87872841-87936273 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 44.45 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1110 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443184
 protein coding gene Chr1:87872841-87936308 (-)
129S1/SvImJ ENSMUSG00200036578
 protein coding gene Chr1:85098149-85160824 (-)
A/J ENSMUSG00195032399
 protein coding gene Chr1:84658670-84721335 (-)
AKR/J ENSMUSG00220041175
 protein coding gene Chr1:84792620-84854942 (-)
BALB/cJ ENSMUSG00180014256
 protein coding gene Chr1:84962074-85024398 (-)
C3H/HeJ ENSMUSG00175001331
 protein coding gene Chr1:84840990-84903314 (-)
C57BL/6NJ ENSMUSG00215019178
 protein coding gene Chr1:84763989-84826315 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014388
 protein coding gene Chr1:80425273-80474661 (-)
CAST/EiJ ENSTCUG00005006706
 protein coding gene Chr1:84391880-84454411 (-)
CBA/J ENSMUSG00210011699
 protein coding gene Chr1:84686295-84748616 (-)
DBA/2J ENSMUSG00185016603
 protein coding gene Chr1:89142971-89205633 (-)
FVB/NJ ENSMUSG00205031218
 protein coding gene Chr1:84092723-84155390 (-)
JF1/MsJ ENSUMUG00000016714
 protein coding gene Chr1:87896900-87959429 (-)
LP/J ENSMUSG00230020397
 protein coding gene Chr1:88427682-88490344 (-)
NOD/ShiLtJ ENSMUSG00190027264
 protein coding gene Chr1:84733500-84796162 (-)
NZO/HlLtJ ENSMUSG00225004324
 protein coding gene Chr1:92330403-92393063 (-)
PWK/PhJ ENSLUMG00010037498
 protein coding gene Chr1:84284106-84346514 (-)
SPRET/EiJ ENSMSPG00010045131
 protein coding gene Chr1:86305618-86376038 (-)
WSB/EiJ ENSIUOG00005040677
 protein coding gene Chr1:84321493-84384140 (-)



Homology
more
  • Human Ortholog
    USP40, ubiquitin specific peptidase 40
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP40, ubiquitin specific peptidase 40
  • Links
    NCBI Gene ID: 55230
    UniProt: Q9NVE5

  • Chr Location
    2q37.1; chr2:233475526-233566782 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    620
  • Tissues
    16
  • cDNA Data
    84
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005501 Ensembl Gene Model | MGI Sequence Detail 63433 C57BL/6J ±  kb
transcript ENSMUST00000187758 Ensembl | MGI Sequence Detail 3977 Not Applicable  
polypeptide ENSMUSP00000140107 Ensembl | MGI Sequence Detail 1235 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000017180 ubiquitin carboxyl-terminal hydrolase 40
    (term hierarchy)
  • EC
    3.4.19.12
  • InterPro Domains
    IPR038765 Papain-like cysteine peptidase superfamily
    IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
    IPR057763 Ubiquitin carboxyl-terminal hydrolase 40, ubiquitin-like domain
    IPR050164 Ubiquitin carboxyl-terminal hydrolases
    IPR018200 Ubiquitin specific protease, conserved site
    IPR028889 Ubiquitin specific protease USP, catalytic domain
Molecular
Reagents
less
  • All nucleic 86
    cDNA 84
    Primer pair 2
    Antibodies 1

    Microarray probesets 4
References
more
  • Summaries
    All 42
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 10
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:346398 Miao J, et al., The deubiquitinase USP40 preserves endothelial integrity by targeting the heat shock protein HSP90beta. Exp Mol Med. 2024 Feb;56(2):395-407
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory