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Mtmr9 Gene Detail
Summary
  • Symbol
    Mtmr9
  • Name
    myotubularin related protein 9
  • Synonyms
    9430075G12Rik, LIP-STYX, MGC:54783, mMTMH3, MTMR8
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442842
    NCBI Gene: 210376
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:63757100-63781402 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 33.32 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    693 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442842
 protein coding gene Chr14:63757100-63781431 (-)
129S1/SvImJ ENSMUSG00200026035
 protein coding gene Chr14:52365693-52390002 (-)
A/J ENSMUSG00195014465
 protein coding gene Chr14:52555862-52580197 (-)
AKR/J ENSMUSG00220027688
 protein coding gene Chr14:51896368-51920702 (-)
BALB/cJ ENSMUSG00180030628
 protein coding gene Chr14:52171971-52196308 (-)
C3H/HeJ ENSMUSG00175030589
 protein coding gene Chr14:53902012-53926321 (-)
C57BL/6NJ ENSMUSG00215013275
 protein coding gene Chr14:52089665-52114004 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019407
 protein coding gene Chr14:54670074-54694736 (-)
CAST/EiJ ENSTCUG00005038758
 protein coding gene Chr14:53824705-53848149 (-)
CBA/J ENSMUSG00210036613
 protein coding gene Chr14:52543354-52567688 (-)
DBA/2J ENSMUSG00185029154
 protein coding gene Chr14:57699814-57724119 (-)
FVB/NJ ENSMUSG00205032727
 protein coding gene Chr14:52058747-52083081 (-)
JF1/MsJ ENSUMUG00000042897
 protein coding gene Chr14:68888419-68914162 (-)
LP/J ENSMUSG00230034857
 protein coding gene Chr14:69729352-69753652 (-)
NOD/ShiLtJ ENSMUSG00190031251
 protein coding gene Chr14:52338129-52362461 (-)
NZO/HlLtJ ENSMUSG00225045483
 protein coding gene Chr14:60071134-60095467 (-)
PWK/PhJ ENSLUMG00010033180
 protein coding gene Chr14:51772245-51797947 (-)
SPRET/EiJ ENSMSPG00010026781
 protein coding gene Chr14:55254229-55277624 (-)
WSB/EiJ ENSIUOG00005039462
 protein coding gene Chr14:51775593-51799897 (-)



Homology
more
  • Human Ortholog
    MTMR9, myotubularin related protein 9
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MTMR9, myotubularin related protein 9
  • Synonyms
    C8orf9, LIP-STYX, MTMR8
  • Links
    NCBI Gene ID: 66036
    UniProt: Q96QG7

  • Chr Location
    8p23.1; chr8:11284523-11339526 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a transposon-induced allele exhibit sublethality at E12.5 and complete lethality at E15.5, and cardiac, vascular system, liver, limb, and eye abnormalities. Heterozygotes for a null allele exhibit a high rate of preweaning leathality, are smaller, and have tremors, ataxia, seizures, and tooth overgrowth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    638
  • Tissues
    7
  • cDNA Data
    9
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 210376 NCBI Gene Model | MGI Sequence Detail 24303 C57BL/6J ±  kb
    transcript NM_177594 RefSeq | MGI Sequence Detail 2457 Not Specified  
    polypeptide Q9Z2D0 UniProt | EBI | MGI Sequence Detail 545 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2145561, MGI:2145592
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 9
    • Earliest
      J:62647 Laporte J, et al., Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human. Hum Mol Genet. 1998 Oct;7(11):1703-12
    • Latest
      J:378174 Yan B, et al., Embryonic Lethal Phenotyping to Identify Candidate Genes Related with Birth Defects. Int J Mol Sci. 2024 Aug 13;25(16)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    09/01/2026
    MGI 6.24     		The Jackson Laboratory