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Tshz3 Gene Detail
Summary
  • Symbol
    Tshz3
  • Name
    teashirt zinc finger family member 3
  • Synonyms
    A630038G13Rik, teashirt3, Tsh3, Zfp537
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442819
    NCBI Gene: 243931
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:36397543-36472978 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 22.79 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    818 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442819
 protein coding gene Chr7:36397543-36472978 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032097
 protein coding gene Chr7:36171725-36252110 (+)
A/J MGP_AJ_G0032077
 protein coding gene Chr7:35184594-35262776 (+)
AKR/J MGP_AKRJ_G0032010
 protein coding gene Chr7:36051555-36128490 (+)
BALB/cJ MGP_BALBcJ_G0032084
 protein coding gene Chr7:35474850-35553321 (+)
C3H/HeJ MGP_C3HHeJ_G0031801
 protein coding gene Chr7:36935691-37014076 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032561
 protein coding gene Chr7:37976442-38055046 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029594
 protein coding gene Chr7:35910318-35985040 (+)
CAST/EiJ MGP_CASTEiJ_G0031136
 protein coding gene Chr7:28151090-28228295 (+)
CBA/J MGP_CBAJ_G0031769
 protein coding gene Chr7:39134307-39216970 (+)
DBA/2J MGP_DBA2J_G0031921
 protein coding gene Chr7:35024301-35103280 (+)
FVB/NJ MGP_FVBNJ_G0031874
 protein coding gene Chr7:34951128-35026873 (+)
LP/J MGP_LPJ_G0031998
 protein coding gene Chr7:36514562-36597151 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031914
 protein coding gene Chr7:38044041-38122553 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032576
 protein coding gene Chr7:35640976-35719367 (+)
PWK/PhJ MGP_PWKPhJ_G0030858
 protein coding gene Chr7:28392898-28469330 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030693
 protein coding gene Chr7:25182665-25265772 (+)
WSB/EiJ MGP_WSBEiJ_G0031246
 protein coding gene Chr7:36169052-36249254 (+)



Homology
more
  • Human Ortholog
    TSHZ3, teashirt zinc finger homeobox 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TSHZ3, teashirt zinc finger homeobox 3
  • Synonyms
    TSH3, ZNF537
  • Links
    NCBI Gene ID: 57616
    neXtProt AC: NX_Q63HK5
    UniProt: Q63HK5

  • Chr Location
    19q12; chr19:31149876-31350877 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tshz3 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit neoatal lethality likely due to respiratory distress and hydroureter and hydronephrosis associated with impaired development of ureteric smooth muscle.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    934
  • Tissues
    187
  • cDNA Data
    22
  • Literature Summary
    29
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 243931 NCBI Gene Model | MGI Sequence Detail 75436 C57BL/6J ±  kb
    transcript NM_172298 RefSeq | MGI Sequence Detail 5098 Not Specified  
    polypeptide Q8CGV9 UniProt | EBI | MGI Sequence Detail 1081 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 22
      Primer pair 1
      Other 3

      Microarray probesets 4
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 29
      Diseases 1
      Gene Ontology 10
      Phenotypes 10
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:327332 Kurz J, et al., GATA6 is a crucial factor for Myocd expression in the visceral smooth muscle cell differentiation program of the murine ureter. Development. 2022 Aug 1;149(15):dev200522
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory